Abstract：
The most prevalent form of inflammatory bowel disease (IBD), ulcerative colitis (UC), is characterized by persistent inflammation of the colorectal mucosa. It is asymptomatic, whereas Crohn\'s disease (CD) causes patchy lesions in the gastrointestinal tract. Men and women suffer equally from ulcerative colitis, which usually strikes in the second and third decades of life and becomes more common in senior citizens. In the present study, we produced zinc oxide nanoparticles using the natural herbal plant, Cassia alata. Zinc oxide nanoparticles have remarkable antimicrobial and antitumor benefits in the field of biomedical science. Furthermore, the synthesized zinc oxide nanoparticles (ZnO NPs) were characterized using UV, XRD, FTIR, and SEM analyses. The XRD analysis confirmed the crystallite nature and purity of the synthesized nanoparticles. Zinc oxide nanoparticles with a uniform size and partially agglomerated morphology were verified by SEM analysis. We investigated the protective effects of environmentally friendly zinc oxide nanoparticles in dextran sodium sulfate-induced ulcerative colitis mouse models. Green synthesized Cassia alata zinc oxide nanoparticles (CA ZnO NPs) reversed weight loss, disease activity index, colon shortening, and colon histological damage. Zinc oxide nanoparticles reduce hypersensitivity, oxidative stress, and inflammation, and protect the mucosal layer. Green synthesized CA ZnO NPs demonstrated protection against dextran sodium sulfate-induced ulcerative colitis via anti-inflammatory activity.
摘要：
炎症性肠病（IBD）的最常见形式，溃疡性结肠炎（UC），其特征在于结肠直肠粘膜的持续炎症。它是无症状的，而克罗恩病（CD）在胃肠道引起斑片状病变。男性和女性同样患有溃疡性结肠炎，这通常发生在生命的第二个和第三个十年，并在老年人中变得更加普遍。在本研究中,我们用天然草药生产氧化锌纳米颗粒，决明子.氧化锌纳米颗粒在生物医学领域具有显著的抗菌和抗肿瘤功效。此外，合成的氧化锌纳米颗粒(ZnONPs)进行了表征,XRD,FTIR,和SEM分析。XRD分析证实了合成的纳米颗粒的微晶性质和纯度。通过SEM分析验证了具有均匀尺寸和部分团聚形态的氧化锌纳米颗粒。我们研究了环境友好型氧化锌纳米颗粒对葡聚糖硫酸钠诱导的溃疡性结肠炎小鼠模型的保护作用。绿色合成决明子氧化锌纳米颗粒（CAZnONPs）逆转失重，疾病活动指数，结肠缩短,和结肠组织学损伤。氧化锌纳米颗粒减少超敏反应，氧化应激，和炎症，并保护粘膜层。Green合成的CAZnONP通过抗炎活性证明了对葡聚糖硫酸钠诱导的溃疡性结肠炎的保护作用。
