Abstract：
Ischemic heart disease (IHD) affects more than 20 million adults in the United States. Although classically attributed to atherosclerosis of the epicardial coronary arteries, nearly half of patients with stable angina and IHD who undergo invasive coronary angiography do not have obstructive epicardial coronary artery disease. Ischemia with nonobstructive coronary arteries is frequently caused by microvascular angina with underlying coronary microvascular dysfunction (CMD). Greater understanding the pathophysiology, diagnosis, and treatment of CMD holds promise to improve clinical outcomes of patients with ischemic heart disease.
摘要：
缺血性心脏病（IHD）影响美国超过2000万成年人。虽然传统上归因于心外膜冠状动脉的动脉粥样硬化，接受侵入性冠状动脉造影的稳定型心绞痛和IHD患者中,近一半没有阻塞性心外膜冠状动脉疾病.非阻塞性冠状动脉缺血通常是由具有潜在冠状动脉微血管功能障碍（CMD）的微血管心绞痛引起的。更好地理解病理生理学，诊断,CMD的治疗有望改善缺血性心脏病患者的临床结局。
