PDF(Pubmed)
Abstract：
Dementia, a prevalent condition in the United States, affecting millions of individuals and their families, underscores the importance of healthy cognitive ageing, which involves maintaining cognitive function and mental wellness as individuals grow older, promoting overall well-being and quality of life. Our original research study investigates the correlation between lifestyle factors and brain atrophy in individuals with mild cognitive impairment (MCI) or Alzheimer\'s disease (AD), as well as healthy older adults. Conducted over six months in West Texas, the research involved 20 participants aged 62-87. Findings reveal that sleep deprivation in MCI subjects and AD patients correlate with posterior cingulate cortex, hippocampal atrophy and total brain volume, while both groups exhibit age-related hippocampal volume reduction. Notably, fruit/vegetable intake negatively correlates with certain brain regions\' volume, emphasizing the importance of diet. Lack of exercise is associated with reduced brain volume and hippocampal atrophy, underlining the cognitive benefits of physical activity. The study underscores lifestyle\'s significant impact on cognitive health, advocating interventions to promote brain health and disease prevention, particularly in MCI/AD cases. While blood profile data showed no significant results regarding cognitive decline, the study underscores the importance of lifestyle modifications in preserving cognitive function.
摘要：
痴呆症,在美国很普遍,影响到数百万个人和他们的家庭，强调了健康认知老化的重要性，这包括随着个体年龄的增长保持认知功能和心理健康，促进整体福祉和生活质量。我们的原始研究调查了生活方式因素与轻度认知障碍（MCI）或阿尔茨海默病（AD）个体脑萎缩之间的相关性。以及健康的老年人。在西德克萨斯进行了六个月，这项研究涉及20名62-87岁的参与者。研究结果表明，MCI受试者和AD患者的睡眠剥夺与后扣带皮质相关，海马萎缩和大脑总体积，而两组均表现出年龄相关的海马体积减少。值得注意的是,水果/蔬菜摄入量与某些大脑区域的体积呈负相关，强调饮食的重要性。缺乏运动与脑容量减少和海马萎缩有关，强调身体活动的认知益处。这项研究强调了生活方式对认知健康的显著影响，倡导促进大脑健康和疾病预防的干预措施，特别是在MCI/AD病例中。虽然血液特征数据显示没有关于认知能力下降的显著结果，该研究强调了改变生活方式对保持认知功能的重要性.
