Abstract：
Many physical, social, and psychological changes occur during aging that raise the risk of developing chronic diseases, frailty, and dependency. These changes adversely affect the gut microbiota, a phenomenon known as microbe-aging. Those microbiota alterations are, in turn, associated with the development of age-related diseases. The gut microbiota is highly responsive to lifestyle and dietary changes, displaying a flexibility that also provides anactionable tool by which healthy aging can be promoted. This review covers, firstly, the main lifestyle and socioeconomic factors that modify the gut microbiota composition and function during healthy or unhealthy aging and, secondly, the advances being made in defining and promoting healthy aging, including microbiome-informed artificial intelligence tools, personalized dietary patterns, and food probiotic systems.
摘要：
许多物理，社会,衰老过程中发生的心理变化会增加患慢性病的风险，脆弱,和依赖性。这些变化对肠道微生物群产生不利影响，一种被称为微生物老化的现象。这些微生物群的改变是，反过来,与年龄相关疾病的发展有关。肠道微生物群对生活方式和饮食变化高度敏感，显示灵活性，也提供了可以促进健康衰老的可操作工具。这篇评论涵盖了，首先,在健康或不健康的衰老过程中改变肠道微生物群组成和功能的主要生活方式和社会经济因素，其次,在定义和促进健康老龄化方面取得的进展，包括微生物组信息人工智能工具，个性化的饮食习惯，和食物益生菌系统。
