PDF(Pubmed)
Abstract：
How human prefrontal and insular regions interact while maximizing rewards and minimizing punishments is unknown. Capitalizing on human intracranial recordings, we demonstrate that the functional specificity toward reward or punishment learning is better disentangled by interactions compared to local representations. Prefrontal and insular cortices display non-selective neural populations to rewards and punishments. Non-selective responses, however, give rise to context-specific interareal interactions. We identify a reward subsystem with redundant interactions between the orbitofrontal and ventromedial prefrontal cortices, with a driving role of the latter. In addition, we find a punishment subsystem with redundant interactions between the insular and dorsolateral cortices, with a driving role of the insula. Finally, switching between reward and punishment learning is mediated by synergistic interactions between the two subsystems. These results provide a unifying explanation of distributed cortical representations and interactions supporting reward and punishment learning.
摘要：
人类前额叶和岛屿区域如何相互作用，同时最大化奖励和最小化惩罚是未知的。利用人类颅内记录，我们证明，与局部表征相比，对奖励或惩罚学习的功能特异性通过相互作用更好地解开。前额叶和岛状皮质显示非选择性神经群体的奖励和惩罚。非选择性反应，然而,产生特定于上下文的区域间互动。我们确定了一个奖励子系统，在眶额叶和腹内侧前额皮质之间具有冗余的相互作用，具有后者的驱动作用。此外,我们发现了一个惩罚子系统，在岛状和背外侧皮层之间有多余的相互作用，具有脑岛的驱动作用。最后,奖惩学习之间的转换是由两个子系统之间的协同相互作用介导的。这些结果为支持奖励和惩罚学习的分布式皮层表示和交互提供了统一的解释。
