Abstract：
OBJECTIVE: The present systematic review and meta-analysis aims to determine the difference in the interdialytic weight gain (IDWG) between low salt intake diet and normal/high salt intake diet or between nutritional counseling aimed at reducing diet salt intake and no nutritional counseling in patients on chronic hemodialysis.
METHODS: Medline, PubMed, Web of Science, and the Cochrane Library were searched. Randomized, crossover or parallel studies and observational studies were considered for inclusion and: 1) included adult patients on chronic hemodialysis since at least 6 months; 2) compared normal salt intake diet with low salt intake diet on IDWG; 3) compared nutritional counseling aimed at reducing diet salt intake with no intervention on IDWG; 4) reported on IDWG.
RESULTS: Eight articles (783 patients) were fully assessed for eligibility and included in the investigation. Meta-analysis showed frequencies of patients that increased their weight after dialysis more than 2.5 Kg (events) over total enrolled subjects for each group (control and experimental). As no significant heterogeneity was observed (I2 = 8%; p = 0.36), the pooled analysis was performed using a fixed-effect model. Funnel plot was generated and no obvious asymmetry was observed. The Overall Odds Ratio to get an event in the experimental group, in respect to controls, is 0.57 (0.33-0.97) (p = 0.04] with single studies OR ranging between 0.11 and 1.08.
CONCLUSIONS: The present systematic review and meta-analysis suggest that the use of a low salt diet sodium or a nutritional counseling aimed at reducing diet salt intake is associated with a statistically significant reduction of the IDWG in patients on chronic hemodialysis.
METHODS: Medline, PubMed, Web of Science, and the Cochrane Library were searched. Randomized, crossover or parallel studies and observational studies were considered for inclusion and: 1) included adult patients on chronic hemodialysis since at least 6 months; 2) compared normal salt intake diet with low salt intake diet on IDWG; 3) compared nutritional counseling aimed at reducing diet salt intake with no intervention on IDWG; 4) reported on IDWG.
RESULTS: Eight articles (783 patients) were fully assessed for eligibility and included in the investigation. Meta-analysis showed frequencies of patients that increased their weight after dialysis more than 2.5 Kg (events) over total enrolled subjects for each group (control and experimental). As no significant heterogeneity was observed (I2 = 8%; p = 0.36), the pooled analysis was performed using a fixed-effect model. Funnel plot was generated and no obvious asymmetry was observed. The Overall Odds Ratio to get an event in the experimental group, in respect to controls, is 0.57 (0.33-0.97) (p = 0.04] with single studies OR ranging between 0.11 and 1.08.
CONCLUSIONS: The present systematic review and meta-analysis suggest that the use of a low salt diet sodium or a nutritional counseling aimed at reducing diet salt intake is associated with a statistically significant reduction of the IDWG in patients on chronic hemodialysis.
摘要：
目的：本系统综述和荟萃分析旨在确定慢性血液透析患者低盐摄入饮食与正常/高盐摄入饮食之间或旨在减少食盐摄入的营养咨询与无营养咨询之间的透析间体重增加（IDWG）差异。
方法：Medline，PubMed,WebofScience,搜索了Cochrane图书馆.随机化,交叉或平行研究和观察性研究被纳入,并且:1)纳入至少6个月以来接受慢性血液透析的成年患者;2)比较IDWG的正常盐摄入饮食和低盐摄入饮食;3)比较旨在减少饮食盐摄入而未对IDWG进行干预的营养咨询;4)IDWG的报道.
结果：对8篇文章（783例患者）的资格进行了全面评估，并纳入了调查。荟萃分析显示，透析后体重增加超过2.5Kg（事件）的患者频率超过每组（对照和实验）的总受试者。由于没有观察到显著的异质性(I2=8%；p=0.36)，采用固定效应模型进行汇总分析.生成漏斗图，未观察到明显的不对称性。在实验组中获得事件的总赔率，在控制方面，为0.57（0.33-0.97）（p=0.04]，单个研究OR范围在0.11和1.08之间。
结论：本系统综述和荟萃分析表明，使用低盐饮食钠或营养咨询旨在减少饮食盐摄入量与慢性血液透析患者IDWG的统计学显著降低相关。
方法：Medline，PubMed,WebofScience,搜索了Cochrane图书馆.随机化,交叉或平行研究和观察性研究被纳入,并且:1)纳入至少6个月以来接受慢性血液透析的成年患者;2)比较IDWG的正常盐摄入饮食和低盐摄入饮食;3)比较旨在减少饮食盐摄入而未对IDWG进行干预的营养咨询;4)IDWG的报道.
结果：对8篇文章（783例患者）的资格进行了全面评估，并纳入了调查。荟萃分析显示，透析后体重增加超过2.5Kg（事件）的患者频率超过每组（对照和实验）的总受试者。由于没有观察到显著的异质性(I2=8%；p=0.36)，采用固定效应模型进行汇总分析.生成漏斗图，未观察到明显的不对称性。在实验组中获得事件的总赔率，在控制方面，为0.57（0.33-0.97）（p=0.04]，单个研究OR范围在0.11和1.08之间。
结论：本系统综述和荟萃分析表明，使用低盐饮食钠或营养咨询旨在减少饮食盐摄入量与慢性血液透析患者IDWG的统计学显著降低相关。
