PDF(Pubmed)
Abstract：
UNASSIGNED: Despite growing interest in psychedelics, there is a lack of routine population-based surveillance of psychedelic microdosing (taking \"subperceptual\" doses of psychedelics, approximately one-twentieth to one-fifth of a full dose, over prolonged periods). Analyzing Google search queries can provide insights into public interest and help address this gap.
UNASSIGNED: To analyze trends in public interest in microdosing in the US through Google search queries and assess their association with cannabis and psychedelic legislative reforms.
UNASSIGNED: In this cross-sectional study, a dynamic event-time difference-in-difference time series analysis was used to assess the impact of cannabis and psychedelic legislation on microdosing search rates from January 1, 2010, to December 31, 2023. Google search rates mentioning \"microdosing,\" \"micro dosing,\" \"microdose,\" or \"micro dose\" within the US and across US states were measured in aggregate.
UNASSIGNED: Enactment of (1) local psychedelic decriminalization laws; (2) legalization of psychedelic-assisted therapy and statewide psychedelic decriminalization; (3) statewide medical cannabis use laws; (4) statewide recreational cannabis use laws; and (5) all cannabis and psychedelic use restricted.
UNASSIGNED: Microdosing searches per 10 million Google queries were measured, examining annual and monthly changes in search rates across the US, including frequency and nature of related searches.
UNASSIGNED: Searches for microdosing in the US remained stable until 2014, then increased annually thereafter, with a cumulative increase by a factor of 13.4 from 2015 to 2023 (7.9 per 10 million to 105.6 per 10 million searches, respectively). In 2023, there were 3.0 million microdosing searches in the US. Analysis at the state level revealed that local psychedelic decriminalization laws were associated with an increase in search rates by 22.4 per 10 million (95% CI, 7.5-37.2), statewide psychedelic therapeutic legalization and decriminalization were associated with an increase in search rates by 28.9 per 10 million (95% CI, 16.5-41.2), statewide recreational cannabis laws were associated with an increase in search rates by 40.9 per 10 million (95% CI, 28.6-53.3), and statewide medical cannabis laws were associated with an increase in search rates by 11.5 per 10 million (95% CI, 6.0-16.9). From August through December 2023, 27.0% of the variation in monthly microdosing search rates between states was explained by differences in cannabis and psychedelics legal status.
UNASSIGNED: This cross-sectional study found that state-led legislative reforms on cannabis and psychedelics were associated with increased public interest in microdosing psychedelics.
UNASSIGNED: To analyze trends in public interest in microdosing in the US through Google search queries and assess their association with cannabis and psychedelic legislative reforms.
UNASSIGNED: In this cross-sectional study, a dynamic event-time difference-in-difference time series analysis was used to assess the impact of cannabis and psychedelic legislation on microdosing search rates from January 1, 2010, to December 31, 2023. Google search rates mentioning \"microdosing,\" \"micro dosing,\" \"microdose,\" or \"micro dose\" within the US and across US states were measured in aggregate.
UNASSIGNED: Enactment of (1) local psychedelic decriminalization laws; (2) legalization of psychedelic-assisted therapy and statewide psychedelic decriminalization; (3) statewide medical cannabis use laws; (4) statewide recreational cannabis use laws; and (5) all cannabis and psychedelic use restricted.
UNASSIGNED: Microdosing searches per 10 million Google queries were measured, examining annual and monthly changes in search rates across the US, including frequency and nature of related searches.
UNASSIGNED: Searches for microdosing in the US remained stable until 2014, then increased annually thereafter, with a cumulative increase by a factor of 13.4 from 2015 to 2023 (7.9 per 10 million to 105.6 per 10 million searches, respectively). In 2023, there were 3.0 million microdosing searches in the US. Analysis at the state level revealed that local psychedelic decriminalization laws were associated with an increase in search rates by 22.4 per 10 million (95% CI, 7.5-37.2), statewide psychedelic therapeutic legalization and decriminalization were associated with an increase in search rates by 28.9 per 10 million (95% CI, 16.5-41.2), statewide recreational cannabis laws were associated with an increase in search rates by 40.9 per 10 million (95% CI, 28.6-53.3), and statewide medical cannabis laws were associated with an increase in search rates by 11.5 per 10 million (95% CI, 6.0-16.9). From August through December 2023, 27.0% of the variation in monthly microdosing search rates between states was explained by differences in cannabis and psychedelics legal status.
UNASSIGNED: This cross-sectional study found that state-led legislative reforms on cannabis and psychedelics were associated with increased public interest in microdosing psychedelics.
摘要：
■尽管人们对迷幻药的兴趣与日俱增，缺乏对迷幻药微量给药的常规基于人群的监测(服用“潜意识”剂量的迷幻药，大约是全剂量的二十分之一到五分之一，长时间)。分析Google搜索查询可以提供对公共利益的见解，并帮助解决这一差距。
■通过Google搜索查询分析美国微剂量的公共利益趋势，并评估其与大麻和迷幻立法改革的关联。
■在这项横断面研究中，从2010年1月1日至2023年12月31日,我们采用动态事件-时差时间序列分析评估大麻和迷幻药物立法对微量给药搜索率的影响.谷歌搜索率提到“微剂量”，“\”微剂量，\"\"微剂量,在美国和美国各州内的“或”微剂量“是汇总测量的。
■颁布（1）当地迷幻药非刑事化法律；（2）迷幻药辅助治疗和全州迷幻药非刑事化的合法化；（3）全州医疗大麻使用法律；（4）全州娱乐性大麻使用法律；（5）所有大麻和迷幻药的使用受到限制。
■测量了每1000万个Google查询的微剂量搜索，检查美国各地搜索率的年度和月度变化，包括相关搜索的频率和性质。
■美国微量给药的搜索在2014年之前保持稳定，此后每年增加，从2015年到2023年，累计增长了13.4倍(每1000万次搜索7.9到每1000万次搜索105.6，分别)。2023年，美国有300万次微剂量搜索。州一级的分析显示，当地的迷幻非刑事化法律与搜索率每1000万增加22.4相关（95％CI，7.5-37.2），全州迷幻治疗合法化和非刑事化与搜索率增加28.9/10百万相关（95％CI，16.5-41.2），全州范围内的休闲大麻法律与搜索率每1000万增加40.9相关（95％CI，28.6-53.3），和全州范围内的医用大麻法律与搜索率每10百万增加11.5相关(95%CI,6.0-16.9).从2023年8月到12月，各州之间每月微量剂量搜索率变化的27.0％是由大麻和迷幻药法律地位的差异解释的。
■这项横断面研究发现，国家主导的大麻和迷幻药立法改革与公众对微剂量迷幻药的兴趣增加有关。
■通过Google搜索查询分析美国微剂量的公共利益趋势，并评估其与大麻和迷幻立法改革的关联。
■在这项横断面研究中，从2010年1月1日至2023年12月31日,我们采用动态事件-时差时间序列分析评估大麻和迷幻药物立法对微量给药搜索率的影响.谷歌搜索率提到“微剂量”，“\”微剂量，\"\"微剂量,在美国和美国各州内的“或”微剂量“是汇总测量的。
■颁布（1）当地迷幻药非刑事化法律；（2）迷幻药辅助治疗和全州迷幻药非刑事化的合法化；（3）全州医疗大麻使用法律；（4）全州娱乐性大麻使用法律；（5）所有大麻和迷幻药的使用受到限制。
■测量了每1000万个Google查询的微剂量搜索，检查美国各地搜索率的年度和月度变化，包括相关搜索的频率和性质。
■美国微量给药的搜索在2014年之前保持稳定，此后每年增加，从2015年到2023年，累计增长了13.4倍(每1000万次搜索7.9到每1000万次搜索105.6，分别)。2023年，美国有300万次微剂量搜索。州一级的分析显示，当地的迷幻非刑事化法律与搜索率每1000万增加22.4相关（95％CI，7.5-37.2），全州迷幻治疗合法化和非刑事化与搜索率增加28.9/10百万相关（95％CI，16.5-41.2），全州范围内的休闲大麻法律与搜索率每1000万增加40.9相关（95％CI，28.6-53.3），和全州范围内的医用大麻法律与搜索率每10百万增加11.5相关(95%CI,6.0-16.9).从2023年8月到12月，各州之间每月微量剂量搜索率变化的27.0％是由大麻和迷幻药法律地位的差异解释的。
■这项横断面研究发现，国家主导的大麻和迷幻药立法改革与公众对微剂量迷幻药的兴趣增加有关。
