PDF(Pubmed)
Abstract：
BACKGROUND: Colletotrichum fungi infect a wide diversity of monocot and dicot hosts, causing diseases on almost all economically important plants worldwide. Colletotrichum is also a suitable model for studying gene family evolution on a fine scale to uncover events in the genome associated with biological changes.
RESULTS: Here we present the genome sequences of 30 Colletotrichum species covering the diversity within the genus. Evolutionary analyses revealed that the Colletotrichum ancestor diverged in the late Cretaceous in parallel with the diversification of flowering plants. We provide evidence of independent host jumps from dicots to monocots during the evolution of Colletotrichum, coinciding with a progressive shrinking of the plant cell wall degradative arsenal and expansions in lineage-specific gene families. Comparative transcriptomics of 4 species adapted to different hosts revealed similarity in gene content but high diversity in the modulation of their transcription profiles on different plant substrates. Combining genomics and transcriptomics, we identified a set of core genes such as specific transcription factors, putatively involved in plant cell wall degradation.
CONCLUSIONS: These results indicate that the ancestral Colletotrichum were associated with dicot plants and certain branches progressively adapted to different monocot hosts, reshaping the gene content and its regulation.
RESULTS: Here we present the genome sequences of 30 Colletotrichum species covering the diversity within the genus. Evolutionary analyses revealed that the Colletotrichum ancestor diverged in the late Cretaceous in parallel with the diversification of flowering plants. We provide evidence of independent host jumps from dicots to monocots during the evolution of Colletotrichum, coinciding with a progressive shrinking of the plant cell wall degradative arsenal and expansions in lineage-specific gene families. Comparative transcriptomics of 4 species adapted to different hosts revealed similarity in gene content but high diversity in the modulation of their transcription profiles on different plant substrates. Combining genomics and transcriptomics, we identified a set of core genes such as specific transcription factors, putatively involved in plant cell wall degradation.
CONCLUSIONS: These results indicate that the ancestral Colletotrichum were associated with dicot plants and certain branches progressively adapted to different monocot hosts, reshaping the gene content and its regulation.
摘要：
背景：炭疽病真菌感染多种单子叶植物和双子叶植物宿主，在全世界几乎所有经济上重要的植物上引起疾病。炭疽病也是一个合适的模型，用于在精细尺度上研究基因家族进化，以揭示基因组中与生物学变化相关的事件。
结果：在这里，我们介绍了30种炭疽病属物种的基因组序列，涵盖了该属内的多样性。进化分析表明，白垩纪晚期的炭疽病祖先与开花植物的多样化同时发生了分歧。我们提供了在Colletotrichum进化过程中从双子叶植物到单子叶植物的独立宿主跳跃的证据，与植物细胞壁降解武器库的逐渐缩小和谱系特异性基因家族的扩展相吻合。适应不同宿主的4个物种的比较转录组学显示，基因含量相似，但在不同植物底物上调节其转录谱的高度多样性。结合基因组学和转录组学，我们确定了一组核心基因，如特定的转录因子，推测参与植物细胞壁降解。
结论：这些结果表明，祖先炭疽病与双子叶植物有关，某些分支逐渐适应不同的单子叶植物寄主，重塑基因含量及其调控。
结果：在这里，我们介绍了30种炭疽病属物种的基因组序列，涵盖了该属内的多样性。进化分析表明，白垩纪晚期的炭疽病祖先与开花植物的多样化同时发生了分歧。我们提供了在Colletotrichum进化过程中从双子叶植物到单子叶植物的独立宿主跳跃的证据，与植物细胞壁降解武器库的逐渐缩小和谱系特异性基因家族的扩展相吻合。适应不同宿主的4个物种的比较转录组学显示，基因含量相似，但在不同植物底物上调节其转录谱的高度多样性。结合基因组学和转录组学，我们确定了一组核心基因，如特定的转录因子，推测参与植物细胞壁降解。
结论：这些结果表明，祖先炭疽病与双子叶植物有关，某些分支逐渐适应不同的单子叶植物寄主，重塑基因含量及其调控。
