PDF(Pubmed)
Abstract：
UNASSIGNED: To compare changes in superficial retinal vascular density (SRVD), deep retinal vascular density (DRVD), and retinal thickness (RT) of the macular zone after repeated low-level red light (RLRL) and 0.01% atropine exposure in premyopic schoolchildren.
UNASSIGNED: Prospective randomized trial. Sixty-nine schoolchildren with cycloplegic refraction >-0.75 D and ≤0.50 D were randomly assigned to RLRL and 0.01% atropine groups. SRVD, DRVD, and RT were measured using swept-source optical coherence tomography at baseline and six months. The macular zone was divided into three concentric rings (fovea, parafovea, and perifovea) using the Early Treatment Diabetic Retinopathy Study.
UNASSIGNED: After six months, the whole, parafoveal, and perifoveal SRVD significantly increased in the two groups (all P < 0.05). Multivariate regression analyses showed that none of these changes varied significantly between the two groups (all P > 0.05), whereas foveal SRVD remained stable in both groups (all P > 0.05). In the RLRL group, the whole and perifoveal DRVD increased significantly (all P < 0.05), whereas no statistical difference was observed in the foveal and parafoveal DRVD. DRVD remained stable in the 0.01% atropine group (all P > 0.05). No significant differences were observed in RT changes between the two groups (all P > 0.05). In comparison, there were no significant changes in SRVD, DRVD, or RT after six months in the placebo group in our previous study.
UNASSIGNED: SRVD increased similarly in the RLRL and 0.01% atropine groups, whereas DRVD increased only in the former group. There were no significant RT changes in either group after six months of treatment in premyopic schoolchildren.
UNASSIGNED: This research observed the effects of low-level red light and 0.01% atropine on retinal vasculature, offering valuable insights into myopia progression prevention.
UNASSIGNED: Prospective randomized trial. Sixty-nine schoolchildren with cycloplegic refraction >-0.75 D and ≤0.50 D were randomly assigned to RLRL and 0.01% atropine groups. SRVD, DRVD, and RT were measured using swept-source optical coherence tomography at baseline and six months. The macular zone was divided into three concentric rings (fovea, parafovea, and perifovea) using the Early Treatment Diabetic Retinopathy Study.
UNASSIGNED: After six months, the whole, parafoveal, and perifoveal SRVD significantly increased in the two groups (all P < 0.05). Multivariate regression analyses showed that none of these changes varied significantly between the two groups (all P > 0.05), whereas foveal SRVD remained stable in both groups (all P > 0.05). In the RLRL group, the whole and perifoveal DRVD increased significantly (all P < 0.05), whereas no statistical difference was observed in the foveal and parafoveal DRVD. DRVD remained stable in the 0.01% atropine group (all P > 0.05). No significant differences were observed in RT changes between the two groups (all P > 0.05). In comparison, there were no significant changes in SRVD, DRVD, or RT after six months in the placebo group in our previous study.
UNASSIGNED: SRVD increased similarly in the RLRL and 0.01% atropine groups, whereas DRVD increased only in the former group. There were no significant RT changes in either group after six months of treatment in premyopic schoolchildren.
UNASSIGNED: This research observed the effects of low-level red light and 0.01% atropine on retinal vasculature, offering valuable insights into myopia progression prevention.
摘要：
■为了比较浅表视网膜血管密度（SRVD）的变化，深视网膜血管密度（DRVD），近视前学龄儿童反复低水平红光（RLRL）和0.01％阿托品暴露后黄斑区的视网膜厚度（RT）。
■前瞻性随机试验。将69名睫状肌麻痹屈光>-0.75D和≤0.50D的学童随机分配到RLRL和0.01％阿托品组。SRVD,DRVD,和RT在基线和6个月时使用扫频源光学相干断层扫描进行测量。黄斑区分为三个同心环(中央凹，Parafovea,和前凹）使用早期治疗糖尿病视网膜病变研究。
■六个月后，整个,侧腹,两组中心凹周围SRVD均显著升高(P均<0.05)。多因素回归分析显示两组间无显著性差异(均P>0.05),而两组中心凹SRVD均保持稳定(均P>0.05)。在RLRL组中，整体和中心凹DRVD显著增加(均P<0.05),而在中央凹和旁凹DRVD中没有观察到统计学差异。0.01%阿托品组DRVD稳定(P均>0.05)。两组患者的RT变化差异均无统计学意义(均P>0.05)。相比之下,SRVD没有显著变化,DRVD,在我们之前的研究中，安慰剂组六个月后进行RT。
■在RLRL和0.01％阿托品组中，SRVD相似地增加，而DRVD仅在前一组增加。近视前学童治疗六个月后，两组的RT均无明显变化。
■这项研究观察了低水平红光和0.01％阿托品对视网膜血管的影响，为预防近视进展提供有价值的见解。
■前瞻性随机试验。将69名睫状肌麻痹屈光>-0.75D和≤0.50D的学童随机分配到RLRL和0.01％阿托品组。SRVD,DRVD,和RT在基线和6个月时使用扫频源光学相干断层扫描进行测量。黄斑区分为三个同心环(中央凹，Parafovea,和前凹）使用早期治疗糖尿病视网膜病变研究。
■六个月后，整个,侧腹,两组中心凹周围SRVD均显著升高(P均<0.05)。多因素回归分析显示两组间无显著性差异(均P>0.05),而两组中心凹SRVD均保持稳定(均P>0.05)。在RLRL组中，整体和中心凹DRVD显著增加(均P<0.05),而在中央凹和旁凹DRVD中没有观察到统计学差异。0.01%阿托品组DRVD稳定(P均>0.05)。两组患者的RT变化差异均无统计学意义(均P>0.05)。相比之下,SRVD没有显著变化,DRVD,在我们之前的研究中，安慰剂组六个月后进行RT。
■在RLRL和0.01％阿托品组中，SRVD相似地增加，而DRVD仅在前一组增加。近视前学童治疗六个月后，两组的RT均无明显变化。
■这项研究观察了低水平红光和0.01％阿托品对视网膜血管的影响，为预防近视进展提供有价值的见解。
