Abstract：
Aim: Compare two vancomycin dosing strategies in critical patients with methicillin-resistant Staphylococcus aureus (MRSA) infections, considering the heterogeneity of the dosing regimens administered and their implications for toxicity and efficacy. Materials & methods: Longitudinal retrospective observational study in two patient cohorts (standard dosing vs dosing via Bayesian algorithms). Results: The group of Bayesian algorithms received substantially higher and significantly heterogeneous doses, with an absence of nephrotoxicity. The speed of decrease observed in CRP and PCT was greater for the Bayesian strategy (p = 0.045 and 0.0009, respectively). Conclusion: Applying Bayesian algorithms to vancomycin dosage individualization allows for administering much higher doses than with standard regimens, facilitating a quicker clinical response in the absence of nephrotoxicity.
[Box: see text].
[Box: see text].
摘要：
目的：比较耐甲氧西林金黄色葡萄球菌（MRSA）感染的危重患者的两种万古霉素给药策略，考虑给药方案的异质性及其对毒性和疗效的影响.材料与方法:在两个患者队列中的纵向回顾性观察研究(标准给药与通过贝叶斯算法给药)。结果：贝叶斯算法组接受了更高和显著异质的剂量，没有肾毒性。对于贝叶斯策略，CRP和PCT的下降速度更大（分别为p=0.045和0.0009）。结论：将贝叶斯算法应用于万古霉素剂量个体化允许施用比标准方案高得多的剂量，在没有肾毒性的情况下促进更快的临床反应。
[方框：见正文]。
[方框：见正文]。
