Abstract：
<b>Introduction:</b> Hemorrhoidal disease is the most common disease treated in proctology ambulatories. Conservative treatment is the basic form of treatment for this disease. One of the elements of treatment may be preparations with myoand phlebotropic effects.<b>Aim:</b> To assess the effect of a multi-ingredient myophlebotropic dietary supplement used as an adjunct on the rate and effectiveness of symptom relief in patients with stage II and III hemorrhoidal disease.<b>Material and method:</b> Patients with stage II and III hemorrhoidal disease with clinical symptoms such as pain, burning, itching and bleeding were qualified for the study. The patients were divided into two groups. The control group (Group I) of 29 patients receiving standard local treatment plus placebo and the study group (Group II) of 32 patients receiving the same local treatment and a six-component myophlebotropic product. Symptoms were analyzed at the time of inclusion in the study (day 0), after 4 and 10 days of therapy. The severity of hemorrhoidal disease and the feeling of relief were assessed on the day of inclusion (W0) and after 30 days of therapy.<b>Results:</b> There were no statistical differences between the groups in terms of disease advancement, age, gender, and duration of symptoms. Compared to the moment of inclusion in the study (W0), after 4 days (W1), after 10 days (W2) of taking the multi- -component product, there was a statistically significant improvement in the VAS scale: spontaneous pain and pain during defecation. In the qualitative assessment (yes/no), there were statistically significantly fewer cases of burning in the anus and itching. The treatment did not affect the rate of spontaneous bleeding, which was low at the beginning of the study, but significantly reduced the rate of bleeding during defecation. After 30 days of observation, it was found that the improvement in the severity of hemorrhoidal disease symptoms was significantly higher in the group using the tested preparation. Relief after a month of the study (one-question method) was noted in the group of patients receiving the tested product.<b>Conclusions:</b> The tested six-component myophlebotropic product proved to be effective in reducing the severity of symptoms such as spontaneous pain, pain during defecation, burning/burning in the anus and bleeding during defecation. Statistical significance was demonstrated in the symptom\'s relief and reduction in the severity of hemorrhoidal disease.
摘要：
<b>简介:</b>痔病是直肠内科门诊治疗的最常见疾病。保守治疗是本病的基本治疗形式。治疗的要素之一可能是具有肌和嗜血作用的制剂。＆lt;b＆gt;目的：＆lt;/b＆gt;评估用作辅助治疗的多种成分的嗜肌性饮食补充剂对II期和III期痔疮患者症状缓解率和有效性的影响。<b>材料和方法:</b>II期和III期痔疮患者有疼痛等临床症状,燃烧,瘙痒和出血为研究合格.将患者分为两组。对照组（I组）为29名患者，接受标准局部治疗加安慰剂，研究组（II组）为32名患者，接受相同的局部治疗和六成分的嗜肌病产品。在纳入研究时（第0天）分析症状，治疗后4天和10天。在纳入当天(W0)和治疗30天后评估痔疮疾病的严重程度和缓解的感觉。<b>结果:</b>在疾病进展方面,组间无统计学差异,年龄,性别,和症状的持续时间。与纳入研究的时刻(W0)相比，4天后（W1），服用多组分产品10天后(W2)，VAS评分有统计学显著改善:自发性疼痛和排便时疼痛.在定性评估(是/否)中，肛门灼热和瘙痒的病例在统计学上明显较少。治疗不影响自发性出血的发生率，这在研究开始时很低，但显著降低排便时出血率。经过30天的观察,发现在使用受试制剂的组中，痔病症状的严重程度的改善明显更高。在接受测试产品的患者组中注意到研究一个月后的缓解(一个问题方法)。<b>结论:</b>经测试的六组分性肌病产品被证明可有效减轻自发性疼痛等症状的严重程度，排便时疼痛,肛门燃烧/燃烧和排便时出血。在痔病的症状缓解和严重程度降低方面具有统计学意义。
