Abstract：
OBJECTIVE: To determine whether individuals with subjective cognitive decline (SCD) have changes in whole-brain network characteristics and intracerebral node characteristics in the structural network, and whether there is a difference between SCD with and without Apolipoprotein E4 (APOEε4).
METHODS: This cross-sectional study included 36 individuals without SCD without APOEε4 (healthy control, HC group), 21 individuals with SCD with APOEε4 (APOEε4+ group), and 33 individuals with SCD without APOEε4 (APOEε4- group). The white matter structural network was constructed using the fractional anisotropy (FA) based deterministic fiber tracking method. Graph theory was used to analyze the whole-brain network characteristics and intracerebral node characteristics of the three groups.
RESULTS: Regarding the whole-brain network characteristics, all three groups exhibited small-worldness in their structural networks. The clustering coefficient (Cp) and local efficiency (Eloc) in the APOEε4+ and APOEε4- groups were significantly lower than in the HC group (p < 0.05), but no significant difference in Cp or Eloc was observed between the APOEε4+ and APOEε4- groups. Regarding intracerebral node characteristics, there were significant differences in some brain regions, mainly the default mode network (DMN), the occipital lobe, the temporal lobe, and subcortical regions. The change in intracerebral node characteristics was different between the APOEε4+ group and the APOEε4- group.
CONCLUSIONS: Individuals with SCD demonstrate changes in whole-brain network characteristics and intracerebral node characteristics in the structural network. Moreover, differences exist between APOEε4+ and APOEε4- individuals.
METHODS: This cross-sectional study included 36 individuals without SCD without APOEε4 (healthy control, HC group), 21 individuals with SCD with APOEε4 (APOEε4+ group), and 33 individuals with SCD without APOEε4 (APOEε4- group). The white matter structural network was constructed using the fractional anisotropy (FA) based deterministic fiber tracking method. Graph theory was used to analyze the whole-brain network characteristics and intracerebral node characteristics of the three groups.
RESULTS: Regarding the whole-brain network characteristics, all three groups exhibited small-worldness in their structural networks. The clustering coefficient (Cp) and local efficiency (Eloc) in the APOEε4+ and APOEε4- groups were significantly lower than in the HC group (p < 0.05), but no significant difference in Cp or Eloc was observed between the APOEε4+ and APOEε4- groups. Regarding intracerebral node characteristics, there were significant differences in some brain regions, mainly the default mode network (DMN), the occipital lobe, the temporal lobe, and subcortical regions. The change in intracerebral node characteristics was different between the APOEε4+ group and the APOEε4- group.
CONCLUSIONS: Individuals with SCD demonstrate changes in whole-brain network characteristics and intracerebral node characteristics in the structural network. Moreover, differences exist between APOEε4+ and APOEε4- individuals.
摘要：
目的：确定主观认知下降（SCD）的个体在结构网络中是否具有全脑网络特征和脑内节点特征的变化，以及有无载脂蛋白E4（APOEε4）的SCD之间是否存在差异。
方法：这项横断面研究包括36名无APOEε4的无SCD个体（健康对照，HC组)，21名患有APOEε4的SCD患者（APOEε4+组），33例SCD无APOEε4（APOEε4组）。使用基于分数各向异性（FA）的确定性纤维跟踪方法构建白质结构网络。采用图论分析三组的全脑网络特征和脑内节点特征。
结果：关于全脑网络特征，这三个群体在他们的结构网络中都表现出了小世界性。APOEε4+和APOEε4-组的聚类系数(Cp)和局部效率(Eloc)均显著低于HC组(p<0.05),但APOEε4+和APOEε4-组之间的Cp或Eloc没有显着差异。关于脑内结节特征，在一些大脑区域有显著差异,主要是默认模式网络(DMN)，枕叶,颞叶,和皮质下区域。APOEeε4+组和APOEeε4-组的脑内结节特征变化不同。
结论：患有SCD的个体表现出全脑网络特征和结构网络中脑内节点特征的变化。此外，APOEε4+和APOEε4-个体之间存在差异。
方法：这项横断面研究包括36名无APOEε4的无SCD个体（健康对照，HC组)，21名患有APOEε4的SCD患者（APOEε4+组），33例SCD无APOEε4（APOEε4组）。使用基于分数各向异性（FA）的确定性纤维跟踪方法构建白质结构网络。采用图论分析三组的全脑网络特征和脑内节点特征。
结果：关于全脑网络特征，这三个群体在他们的结构网络中都表现出了小世界性。APOEε4+和APOEε4-组的聚类系数(Cp)和局部效率(Eloc)均显著低于HC组(p<0.05),但APOEε4+和APOEε4-组之间的Cp或Eloc没有显着差异。关于脑内结节特征，在一些大脑区域有显著差异,主要是默认模式网络(DMN)，枕叶,颞叶,和皮质下区域。APOEeε4+组和APOEeε4-组的脑内结节特征变化不同。
结论：患有SCD的个体表现出全脑网络特征和结构网络中脑内节点特征的变化。此外，APOEε4+和APOEε4-个体之间存在差异。
