Abstract：
Antibiotic resistance has progressively diminished the effectiveness of conventional antibiotics, necessitating the cessation of clinical treatment. Consequently, novel antibacterial agents are urgently needed. We review studies on antimicrobial agents published during 2002-2023. Most of these studies were published within the last 10 years. By analyzing recent articles on antibiotic resistance and the development of new antibacterial drugs, we showed that although drug resistance is inevitable, the issue is being addressed gradually via the discovery and clinical application of antimicrobial peptides, nanomaterial drugs, and bacteriophage therapy. In light of the emergence of antimicrobial resistance, the development of new antimicrobial agents will require innovation in a field that has relied on traditional methods of discovery and development.
摘要：
抗生素耐药性逐渐削弱了传统抗生素的有效性。必须停止临床治疗。因此,迫切需要新型抗菌剂。我们回顾了2002-2023年期间发表的关于抗菌药物的研究。这些研究大多是在过去10年中发表的。通过分析最近关于抗生素耐药性和新抗菌药物开发的文章，我们表明，尽管抗药性是不可避免的，通过抗菌肽的发现和临床应用，纳米材料药物，和噬菌体疗法.鉴于抗菌素耐药性的出现，新的抗微生物剂的开发将需要在依赖传统发现和开发方法的领域进行创新。
