Abstract：
BACKGROUND: Pelvic congestion syndrome (PCS) is associated with chronic pelvic pain (CPP). The efficacy of flavonoids for treating PCS symptoms is still a matter of debate, and little has been published. The aim of this study was to assess the efficacy of a mixture of diosmin, troxerutin, and hesperidin in improving symptoms of patients with PCS, observing a direct effect on circulation by specific color Doppler ultrasonography (CDU) evaluations.
METHODS: This was a pilot, prospective, independent, cross-over, daily-diary-based trial. Women were evaluated with CDU for 3 times (baseline, 60 days, 120 days). Data about N.=13 women who completed the study were analyzed.
RESULTS: During the treatment, we recorded a significant reduction of intermenstrual and menstrual pain intensity (total points) (P<0.05). The satisfaction after treatment was significantly higher than after placebo (P<0.0001). A significant reduction in the diameter of the major ovarian vein (P=0.004 compared to placebo), associated with an increase in peak systolic velocity (P=0.01) and a corresponding significant increase in the Resistivity Index (P<0.0001) were recorded during treatment.
CONCLUSIONS: The use of a mixture of diosmin, troxerutin and hesperidin in women with PCS can significantly help to manage typical symptoms of pelvic pain and it is associated with an evident Doppler effect on pelvic microcirculation.
METHODS: This was a pilot, prospective, independent, cross-over, daily-diary-based trial. Women were evaluated with CDU for 3 times (baseline, 60 days, 120 days). Data about N.=13 women who completed the study were analyzed.
RESULTS: During the treatment, we recorded a significant reduction of intermenstrual and menstrual pain intensity (total points) (P<0.05). The satisfaction after treatment was significantly higher than after placebo (P<0.0001). A significant reduction in the diameter of the major ovarian vein (P=0.004 compared to placebo), associated with an increase in peak systolic velocity (P=0.01) and a corresponding significant increase in the Resistivity Index (P<0.0001) were recorded during treatment.
CONCLUSIONS: The use of a mixture of diosmin, troxerutin and hesperidin in women with PCS can significantly help to manage typical symptoms of pelvic pain and it is associated with an evident Doppler effect on pelvic microcirculation.
摘要：
背景：盆腔淤血综合征（PCS）与慢性盆腔疼痛（CPP）相关。黄酮类化合物治疗PCS症状的疗效仍是一个争论的问题，很少发表。这项研究的目的是评估Diosmin混合物的功效，曲克鲁汀,和橙皮苷改善PCS患者的症状，通过特定的彩色多普勒超声（CDU）评估观察对循环的直接影响。
方法：这是一个试点项目，prospective,独立,cross-over,每日日记为基础的试验。女性用CDU评估3次(基线，60天,120天）。分析了完成研究的13名妇女的数据。
结果：治疗期间，我们记录到月经间期和月经疼痛强度（总分）显着降低（P<0.05）。治疗后满意度明显高于安慰剂治疗后(P<0.0001)。卵巢大静脉直径显著减少（与安慰剂相比P=0.004），与收缩期峰值速度增加(P=0.01)和相应的电阻率指数显著增加(P<0.0001)相关.
结论：使用地奥司明的混合物，在PCS患者中，曲克鲁丁和橙皮苷可以显着帮助控制盆腔疼痛的典型症状，并且与对盆腔微循环的明显多普勒效应有关。
方法：这是一个试点项目，prospective,独立,cross-over,每日日记为基础的试验。女性用CDU评估3次(基线，60天,120天）。分析了完成研究的13名妇女的数据。
结果：治疗期间，我们记录到月经间期和月经疼痛强度（总分）显着降低（P<0.05）。治疗后满意度明显高于安慰剂治疗后(P<0.0001)。卵巢大静脉直径显著减少（与安慰剂相比P=0.004），与收缩期峰值速度增加(P=0.01)和相应的电阻率指数显著增加(P<0.0001)相关.
结论：使用地奥司明的混合物，在PCS患者中，曲克鲁丁和橙皮苷可以显着帮助控制盆腔疼痛的典型症状，并且与对盆腔微循环的明显多普勒效应有关。
