Abstract：
Aging refers to a progressive decline in biological functions, leading to age-related diseases and mortality. The transition metals, including iron, copper, and manganese, play important roles in human physiological and pathological processes. Substantial research has demonstrated that senescent cells accumulate higher levels of transition metals, which in turn accelerates the process of cellular senescence and related diseases through mechanisms such as production of excessive reactive oxygen species (ROS), induction of oxidative stress, DNA damage, and mitochondrial dysfunction. This review article provides a comprehensive overview of the causes of transition metal accumulation in senescent cells, as well as the mechanisms by which it further promotes cellular senescence and related diseases. The aim is to provide insights into anti-aging and treatment of aging-related diseases caused by transition metal accumulation.
摘要：
衰老是指生物功能的逐渐下降，导致与年龄有关的疾病和死亡率。过渡金属，包括铁,铜，和锰，在人体生理和病理过程中发挥重要作用。大量研究表明，衰老细胞积累了更高水平的过渡金属，这反过来又加速了细胞衰老和相关疾病的过程，通过机制，如产生过量的活性氧（ROS），氧化应激的诱导，DNA损伤,和线粒体功能障碍。这篇综述文章全面概述了衰老细胞中过渡金属积累的原因，以及它进一步促进细胞衰老和相关疾病的机制。目的是为抗衰老和治疗由过渡金属积累引起的衰老相关疾病提供见解。
