PDF(Pubmed)
Abstract：
Ginsenosides, the primary bioactive ingredients derived from the root of Panax ginseng, are eagerly in demand for tumor patients as a complementary and alternative drug. Ginsenosides have increasingly become a \"hot topic\" in recent years due to their multifunctional role in treating colorectal cancer (CRC) and regulating tumor microenvironment (TME). Emerging experimental research on ginsenosides in the treatment and immune regulation of CRC has been published, while no review sums up its specific role in the CRC microenvironment. Therefore, this paper systematically introduces how ginsenosides affect the TME, specifically by enhancing immune response, inhibiting the activation of stromal cells, and altering the hallmarks of CRC cells. In addition, we discuss their impact on the physicochemical properties of the tumor microenvironment. Furthermore, we discuss the application of ginsenosides in clinical treatment as their efficacy in enhancing tumor patient immunity and prolonging survival. The future perspectives of ginsenoside as a complementary and alternative drug of CRC are also provided. This review hopes to open up a new horizon for the cancer treatment of Traditional Chinese Medicine monomers.
摘要：
人参皂苷,人参根的主要生物活性成分，肿瘤患者迫切需要作为补充和替代药物。人参皂苷因其在治疗结直肠癌(CRC)和调节肿瘤微环境(TME)方面的多功能作用,近年来日益成为"热门话题"。人参皂苷在CRC治疗和免疫调节中的新兴实验研究已经发表，虽然没有综述总结其在CRC微环境中的具体作用。因此,本文系统地介绍了人参皂苷对TME的影响,特别是通过增强免疫反应，抑制基质细胞的激活，改变CRC细胞的标志。此外,我们讨论了它们对肿瘤微环境理化性质的影响。此外，我们讨论了人参皂苷在临床治疗中的应用，以提高肿瘤患者的免疫力和延长生存期。并对人参皂苷作为CRC的补充和替代药物的前景进行了展望。本综述希望为中药单体治疗肿瘤开辟新的视野。
