PDF(Pubmed)
Abstract：
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymopathy in humans. G6PD is an essential enzyme in the pentose phosphate pathway (PPP), generating NADPH needed for cellular biosynthesis and reactive oxygen species (ROS) homeostasis, the latter especially key in red blood cells (RBCs). Beyond the RBC, there is emerging evidence that G6PD exerts an immunologic role by virtue of its functions in leukocyte oxidative metabolism and anabolic synthesis necessary for immune effector function. We review these here, and consider the global immunometabolic role of G6PD activity and G6PD deficiency in modulating inflammation and immunopathology.
摘要：
葡萄糖-6-磷酸脱氢酶（G6PD）缺乏症是人类最常见的酶病。G6PD是戊糖磷酸途径（PPP）中的必需酶，产生细胞生物合成和活性氧（ROS）稳态所需的NADPH，后者在红细胞（RBC）中尤为关键。在RBC之外,有新的证据表明，G6PD由于其在白细胞氧化代谢和合成代谢合成中的功能而发挥免疫作用，这是免疫效应功能所必需的。我们在这里回顾这些，并考虑G6PD活性和G6PD缺乏在调节炎症和免疫病理学中的总体免疫代谢作用。
