PDF(Pubmed)
Abstract：
UNASSIGNED: This study aimed to evaluate the relationship between systemic immune-inflammation index (SII) and sex hormones in children and adolescents aged 6-19 years.
UNASSIGNED: Data were obtained from the National Health and Nutrition Examination Survey (NHANES) conducted between 2013 and 2016. Inclusion criteria comprised subjects aged 6-19 years with complete data on both SII and sex hormones. We employed weighted multiple regression analysis and subgroup analytical methods to independently estimate the relationship between SII and sex hormones.
UNASSIGNED: In this study, a total of 3767 participants were included, with an average age of 12.32 ± 3.95 years. Males constituted 50.54%, and females 49.46%. Among males, a statistically significant negative correlation emerged between SII and sex hormone-binding globulin (SHBG). Similarly, in the female population, SII exhibited a statistically significant negative correlation with total testosterone (TT), SHBG, and the Ratio of TT to estradiol, while maintaining a positive correlation with free androgen index (FAI). Subgroup analysis underscored variances in the association between sex hormones and SII within cohorts distinguished by pubertal status or different body mass index (BMI). In addition, the relationship between SII and estradiol exhibited nonlinearity. Employing a two-segment linear regression model, we identified an inverted U-shaped association between SII and estradiol, with an inflection point of 748.09 (1000cell/ml).
UNASSIGNED: Our findings suggest that SII may be an independent risk factor for changes in sex hormones in both male and female children and adolescents. More prospective and experimental studies should be conducted to validate our results and elucidate the underlying molecular pathways.
UNASSIGNED: Data were obtained from the National Health and Nutrition Examination Survey (NHANES) conducted between 2013 and 2016. Inclusion criteria comprised subjects aged 6-19 years with complete data on both SII and sex hormones. We employed weighted multiple regression analysis and subgroup analytical methods to independently estimate the relationship between SII and sex hormones.
UNASSIGNED: In this study, a total of 3767 participants were included, with an average age of 12.32 ± 3.95 years. Males constituted 50.54%, and females 49.46%. Among males, a statistically significant negative correlation emerged between SII and sex hormone-binding globulin (SHBG). Similarly, in the female population, SII exhibited a statistically significant negative correlation with total testosterone (TT), SHBG, and the Ratio of TT to estradiol, while maintaining a positive correlation with free androgen index (FAI). Subgroup analysis underscored variances in the association between sex hormones and SII within cohorts distinguished by pubertal status or different body mass index (BMI). In addition, the relationship between SII and estradiol exhibited nonlinearity. Employing a two-segment linear regression model, we identified an inverted U-shaped association between SII and estradiol, with an inflection point of 748.09 (1000cell/ml).
UNASSIGNED: Our findings suggest that SII may be an independent risk factor for changes in sex hormones in both male and female children and adolescents. More prospective and experimental studies should be conducted to validate our results and elucidate the underlying molecular pathways.
摘要：
■本研究旨在评估6-19岁儿童和青少年的全身免疫炎症指数（SII）与性激素之间的关系。
■数据来自2013年至2016年进行的国家健康和营养检查调查（NHANES）。纳入标准包括年龄在6-19岁的受试者，其具有关于SII和性激素的完整数据。我们采用加权多元回归分析和亚组分析方法来独立估计SII与性激素之间的关系。
■在这项研究中，共包括3767名参与者，平均年龄12.32±3.95岁。男性占50.54%，女性占49.46%。在男性中，SII与性激素结合球蛋白(SHBG)之间出现统计学显著的负相关.同样，在女性人口中，SII与总睾酮（TT）呈统计学显著负相关，SHBG,和TT与雌二醇的比率，同时与游离雄激素指数（FAI）保持正相关。亚组分析强调了按青春期状态或不同体重指数（BMI）区分的队列中性激素与SII之间关联的差异。此外,SII与雌二醇的关系呈非线性。采用两段线性回归模型，我们确定了SII和雌二醇之间的倒U型关联，拐点为748.09（1000cell/ml）。
■我们的研究结果表明，SII可能是男性和女性儿童和青少年性激素变化的独立危险因素。应该进行更多的前瞻性和实验性研究来验证我们的结果并阐明潜在的分子途径。
■数据来自2013年至2016年进行的国家健康和营养检查调查（NHANES）。纳入标准包括年龄在6-19岁的受试者，其具有关于SII和性激素的完整数据。我们采用加权多元回归分析和亚组分析方法来独立估计SII与性激素之间的关系。
■在这项研究中，共包括3767名参与者，平均年龄12.32±3.95岁。男性占50.54%，女性占49.46%。在男性中，SII与性激素结合球蛋白(SHBG)之间出现统计学显著的负相关.同样，在女性人口中，SII与总睾酮（TT）呈统计学显著负相关，SHBG,和TT与雌二醇的比率，同时与游离雄激素指数（FAI）保持正相关。亚组分析强调了按青春期状态或不同体重指数（BMI）区分的队列中性激素与SII之间关联的差异。此外,SII与雌二醇的关系呈非线性。采用两段线性回归模型，我们确定了SII和雌二醇之间的倒U型关联，拐点为748.09（1000cell/ml）。
■我们的研究结果表明，SII可能是男性和女性儿童和青少年性激素变化的独立危险因素。应该进行更多的前瞻性和实验性研究来验证我们的结果并阐明潜在的分子途径。
