PDF(Pubmed)
Abstract：
UNASSIGNED: The intramuscular (IM) administration of 7.5-10 mg/kg of alfaxalone produces anesthetic effects that enable endotracheal intubation with mild cardiorespiratory depression in dogs. However, the effects of IM co-administration of medetomidine, butorphanol, and alfaxalone on cardiorespiratory function under inhalation anesthesia have not been studied.
UNASSIGNED: To assess the cardiorespiratory function following the IM co-administration of 5 μg/kg of medetomidine, 0.3 mg/kg of butorphanol, and 2.5 mg/kg of alfaxalone (MBA) in dogs anesthetized with sevoflurane.
UNASSIGNED: Seven intact healthy Beagles (three males and four females, aged 3-6 years old and weighing 10.0-18.1 kg) anesthetized with a predetermined minimum alveolar concentration (MAC) of sevoflurane were included in this study. The baseline cardiorespiratory variable values were recorded using the thermodilution method with a pulmonary artery catheter after stabilization for 15 minutes at 1.3 times their individual sevoflurane MAC. The cardiorespiratory variables were measured again following the IM administration of MBA. Data are expressed as median [interquartile range] and compared with the corresponding baseline values using the Friedman test and Sheff\'s method. A p < 0.05 was considered statistically significant.
UNASSIGNED: The intramuscular administration of MBA transiently decreased the cardiac index [baseline: 3.46 (3.18-3.69), 5 minutes: 1.67 (1.57-1.75) l/minute/m2 : p < 0.001], respiratory frequency, and arterial pH. In contrast, it increased the systemic vascular resistance index [baseline: 5,367 (3,589-6,617), 5 minutes:10,197 (9,955-15,005) dynes second/cm5/m2 : p = 0.0092], mean pulmonary arterial pressure, and arterial partial pressure of carbon dioxide.
UNASSIGNED: The intramuscular administration of MBA in dogs anesthetized with sevoflurane transiently decreased cardiac output due to vasoconstriction. Although spontaneous breathing was maintained, MBA administration resulted in respiratory acidosis due to hypoventilation. Thus, it is important to administer MBA with caution to dogs with insufficient cardiovascular function. In addition, ventilatory support is recommended.
UNASSIGNED: To assess the cardiorespiratory function following the IM co-administration of 5 μg/kg of medetomidine, 0.3 mg/kg of butorphanol, and 2.5 mg/kg of alfaxalone (MBA) in dogs anesthetized with sevoflurane.
UNASSIGNED: Seven intact healthy Beagles (three males and four females, aged 3-6 years old and weighing 10.0-18.1 kg) anesthetized with a predetermined minimum alveolar concentration (MAC) of sevoflurane were included in this study. The baseline cardiorespiratory variable values were recorded using the thermodilution method with a pulmonary artery catheter after stabilization for 15 minutes at 1.3 times their individual sevoflurane MAC. The cardiorespiratory variables were measured again following the IM administration of MBA. Data are expressed as median [interquartile range] and compared with the corresponding baseline values using the Friedman test and Sheff\'s method. A p < 0.05 was considered statistically significant.
UNASSIGNED: The intramuscular administration of MBA transiently decreased the cardiac index [baseline: 3.46 (3.18-3.69), 5 minutes: 1.67 (1.57-1.75) l/minute/m2 : p < 0.001], respiratory frequency, and arterial pH. In contrast, it increased the systemic vascular resistance index [baseline: 5,367 (3,589-6,617), 5 minutes:10,197 (9,955-15,005) dynes second/cm5/m2 : p = 0.0092], mean pulmonary arterial pressure, and arterial partial pressure of carbon dioxide.
UNASSIGNED: The intramuscular administration of MBA in dogs anesthetized with sevoflurane transiently decreased cardiac output due to vasoconstriction. Although spontaneous breathing was maintained, MBA administration resulted in respiratory acidosis due to hypoventilation. Thus, it is important to administer MBA with caution to dogs with insufficient cardiovascular function. In addition, ventilatory support is recommended.
摘要：
■肌内（IM）施用7.5-10mg/kg的阿法沙酮产生麻醉作用，使气管内插管在狗中具有轻度心肺抑制。然而,IM联合给药美托咪定的效果，布托啡诺,和阿法沙松对吸入麻醉下心肺功能的影响尚未研究。
■为了评估IM共给药5μg/kg美托咪定后的心肺功能，0.3mg/kg布托啡诺，和用七氟醚麻醉的狗使用2.5mg/kg的阿法沙酮（MBA）。
■7只健康的小猎犬（3只雄性和4只雌性，年龄3-6岁，体重10.0-18.1kg）以预定最低肺泡浓度（MAC）的七氟烷麻醉纳入本研究。在其各自七氟醚MAC的1.3倍稳定15分钟后，使用肺动脉导管使用热稀释法记录基线心肺变量值。在IM施用MBA后再次测量心肺变量。数据表示为中值[四分位距],并使用Friedman检验和Sheff's方法与相应的基线值进行比较。P<0.05被认为是统计学上显著的。
■肌内施用MBA会短暂降低心脏指数[基线：3.46（3.18-3.69），5分钟：1.67（1.57-1.75）l/min/m2：p<0.001]，呼吸频率,和动脉pH值。相比之下,它增加了全身血管阻力指数[基线：5,367（3,589-6,617），5分钟：10,197（9,955-15,005）达因秒/cm5/m2：p=0.0092]，平均肺动脉压,和二氧化碳的动脉分压。
■七氟醚麻醉的犬肌内施用MBA会由于血管收缩而暂时降低心输出量。尽管保持了自主呼吸，MBA管理导致呼吸性酸中毒由于通气不足。因此，对于心血管功能不足的狗，谨慎管理MBA很重要。此外,建议支持通气。
■为了评估IM共给药5μg/kg美托咪定后的心肺功能，0.3mg/kg布托啡诺，和用七氟醚麻醉的狗使用2.5mg/kg的阿法沙酮（MBA）。
■7只健康的小猎犬（3只雄性和4只雌性，年龄3-6岁，体重10.0-18.1kg）以预定最低肺泡浓度（MAC）的七氟烷麻醉纳入本研究。在其各自七氟醚MAC的1.3倍稳定15分钟后，使用肺动脉导管使用热稀释法记录基线心肺变量值。在IM施用MBA后再次测量心肺变量。数据表示为中值[四分位距],并使用Friedman检验和Sheff's方法与相应的基线值进行比较。P<0.05被认为是统计学上显著的。
■肌内施用MBA会短暂降低心脏指数[基线：3.46（3.18-3.69），5分钟：1.67（1.57-1.75）l/min/m2：p<0.001]，呼吸频率,和动脉pH值。相比之下,它增加了全身血管阻力指数[基线：5,367（3,589-6,617），5分钟：10,197（9,955-15,005）达因秒/cm5/m2：p=0.0092]，平均肺动脉压,和二氧化碳的动脉分压。
■七氟醚麻醉的犬肌内施用MBA会由于血管收缩而暂时降低心输出量。尽管保持了自主呼吸，MBA管理导致呼吸性酸中毒由于通气不足。因此，对于心血管功能不足的狗，谨慎管理MBA很重要。此外,建议支持通气。
