Abstract：
Compounded medicines are widely used, especially for pediatric patients. The aim of this study was to evaluate children\'s acceptability of compounded preparations and to provide information regarding compounding practices\' characteristics in a Romanian hospital setting. An observational, cross-sectional, and retrospective study was conducted in three Clinical Pediatric Departments (Emergency Clinical Hospital for Children, Cluj-Napoca). The study population comprised patients under 18 years old taking at least one compounded medication. Study data was collected mainly through an interviewer-administered questionnaire and medicine acceptability was assessed based on the children\'s first reaction to the preparations using a 3-point facial hedonic scale. A total of 162 compounded medications were evaluated. A positive/negative reaction was reported for 20.83%/58.33%, 20.63%/49.21%, and 66.67%/7.41% of oral, oromucosal and cutaneous dosage forms. Although patient disapproval was recorded for various reasons, medication administration was successful in over 75% of cases. Factors such as fewer steps required for intake of a dose, capsule dosage form, no additional food/drink immediately after drug intake, medication perceived as \"easy/very easy\" to swallow, were correlated with a better acceptability of oral preparations. This study highlights the importance of identifying factors that can improve the acceptability of compounded preparations and, subsequently, treatment outcomes in pediatric patients.
摘要：
复合药物被广泛使用，尤其是儿科患者。这项研究的目的是评估儿童对复合制剂的可接受性，并提供有关罗马尼亚医院环境中复合实践特征的信息。一个观察,横截面,并在三个临床儿科部门进行了回顾性研究(急诊儿童临床医院，克鲁-纳波卡）。研究人群包括服用至少一种复合药物的18岁以下患者。研究数据主要通过面试官管理的问卷收集，并根据儿童对制剂的第一反应使用3点面部享乐量表评估药物可接受性。总共评估了162种复合药物。阳性/阴性反应报告为20.83%/58.33%，20.63%/49.21%，和66.67%/7.41%的口服，口腔粘膜和皮肤剂型。尽管由于各种原因记录了患者的不赞成，超过75%的病例给药成功.诸如摄入剂量所需的步骤较少，胶囊剂型,药物摄入后立即没有额外的食物/饮料，被认为“容易/非常容易”吞咽的药物，与口服制剂的更好接受度相关。这项研究强调了确定可以提高复合制剂可接受性的因素的重要性，随后,儿科患者的治疗结果。
