Abstract：
Metal ions carry out a wide variety of functions, including acid-base/redox catalysis, structural functions, signaling, and electron transport. Understanding the interactions of transition metal complexes with biomacromolecules is essential for biology, medicinal chemistry, and the production of synthetic metalloenzymes. After the coincidental discovery of cisplatin, importance of the metal complexes in biochemistry became a top priority for inquiry. In this review, a decade update on various synthetic strategies to first row transition metal complex and their interaction with DNA through non-covalent binding are explored. Moreover, this effort provides an excellent analysis on the efficacy of theoretical and practical approaches to the systematic generation of new non-platinum based metallodrugs for anti-cancer therapeutics.
摘要：
金属离子执行各种各样的功能，包括酸碱/氧化还原催化，结构功能，信令,和电子传输。了解过渡金属配合物与生物大分子的相互作用对生物学至关重要。药物化学,以及合成金属酶的生产。顺铂偶然发现后,金属络合物在生物化学中的重要性成为探究的重中之重。在这次审查中,对第一行过渡金属络合物的各种合成策略及其通过非共价结合与DNA的相互作用进行了十年的更新。此外，这项工作对理论和实践方法的有效性进行了出色的分析，以系统地生成用于抗癌治疗的新型非铂类金属药物。
