Abstract：
BACKGROUND: The absolute requirement for a long-term favorable result with cytoreductive surgery for pseudomyxoma peritonei is a complete resection of all visible disease. A combination of parietal peritonectomy procedures and visceral resections is required for this to occur. The cytoreductive surgery is supplemented by hyperthermic intraperitoneal chemotherapy.
METHODS: We searched our database and secured files for patients who required a total gastrectomy and a total colectomy to achieve a complete cytoreductive surgery. Survival of low-grade mucinous neoplasm (LAMN) and mucinous appendiceal adenocarcinoma (MACA) histologies were determined. Clinical and histologic variables were assessed for their impact on survival.
RESULTS: Thirteen of 450 patients (2.9%) with LAMN histology and 14 of 186 patients (7.5%) with MACA histology had these visceral resections. Median survival of these 27 patients was 10 years. LAMN and MACA patients showed the same survival. For LAMN histology, this requirement for extensive visceral resection markedly reduced survival (p < 0.0001). For MACA, there was no adverse impact on survival (p = 0.4359). Class 4 adverse events caused reduced survival (p = 0.0014).
CONCLUSIONS: A 10-year median survival accompanies total gastrectomy plus total colectomy for advanced pseudomyxoma peritonei. Systemic chemotherapy and class 4 adverse events reduced survival.
METHODS: We searched our database and secured files for patients who required a total gastrectomy and a total colectomy to achieve a complete cytoreductive surgery. Survival of low-grade mucinous neoplasm (LAMN) and mucinous appendiceal adenocarcinoma (MACA) histologies were determined. Clinical and histologic variables were assessed for their impact on survival.
RESULTS: Thirteen of 450 patients (2.9%) with LAMN histology and 14 of 186 patients (7.5%) with MACA histology had these visceral resections. Median survival of these 27 patients was 10 years. LAMN and MACA patients showed the same survival. For LAMN histology, this requirement for extensive visceral resection markedly reduced survival (p < 0.0001). For MACA, there was no adverse impact on survival (p = 0.4359). Class 4 adverse events caused reduced survival (p = 0.0014).
CONCLUSIONS: A 10-year median survival accompanies total gastrectomy plus total colectomy for advanced pseudomyxoma peritonei. Systemic chemotherapy and class 4 adverse events reduced survival.
摘要：
背景：对腹膜假性黏液瘤的细胞减灭术的长期有利结果的绝对要求是完全切除所有可见的疾病。要做到这一点，需要结合顶叶周围切除术和内脏切除术。细胞减灭术辅以腹腔热化疗。
方法：我们搜索了我们的数据库并确保了需要进行全胃切除术和全结肠切除术以实现完整的细胞减灭术的患者的文件。确定了低度粘液性肿瘤（LAMN）和粘液性阑尾腺癌（MACA）组织学的存活率。评估临床和组织学变量对生存率的影响。
结果：450例LAMN组织学患者中有13例（2.9％），186例MACA组织学患者中有14例（7.5％）进行了内脏切除。这27例患者的中位生存期为10年。LAMN和MACA患者的生存率相同。对于LAMN组织学，这种广泛内脏切除的要求显著降低了生存率(p<0.0001).对于MACA，对生存率无不良影响(p=0.4359).4类不良事件导致生存率降低（p=0.0014）。
结论：晚期腹膜假性黏液瘤的10年中位生存期伴随全胃切除术加结肠切除术。全身化疗和4类不良事件降低了生存率。
方法：我们搜索了我们的数据库并确保了需要进行全胃切除术和全结肠切除术以实现完整的细胞减灭术的患者的文件。确定了低度粘液性肿瘤（LAMN）和粘液性阑尾腺癌（MACA）组织学的存活率。评估临床和组织学变量对生存率的影响。
结果：450例LAMN组织学患者中有13例（2.9％），186例MACA组织学患者中有14例（7.5％）进行了内脏切除。这27例患者的中位生存期为10年。LAMN和MACA患者的生存率相同。对于LAMN组织学，这种广泛内脏切除的要求显著降低了生存率(p<0.0001).对于MACA，对生存率无不良影响(p=0.4359).4类不良事件导致生存率降低（p=0.0014）。
结论：晚期腹膜假性黏液瘤的10年中位生存期伴随全胃切除术加结肠切除术。全身化疗和4类不良事件降低了生存率。
