PDF(Pubmed)
Abstract：
BACKGROUND: High blood pressure, also known as hypertension (HTN), is a complicated disorder that is controlled by a complex network of physiological processes. Untreated hypertension is associated with increased death incidence, rise the need for understanding the genetic basis affecting hypertension susceptibility and development. The current study sought to identify the genetic association between twelve single nucleotide polymorphisms (SNPs) within seven candidate genes (NOS3, NOS1AP, REN, PLA2G4A, TCF7L, ADRB1, and PTPRD).
METHODS: The current study included 200 Jordanian individuals diagnosed with hypertension, compared to 224 healthy controls. Whole blood samples were drawn from each individual for DNA isolation and genotyping. The SNPStats tool was used to assess haplotype, genotype, and allele frequencies by the mean of chi-square (χ2).
RESULTS: Except for rs10739150 of PTPRD (P = 0.0003), the genotypic and allelic distribution of the SNP was identical between patients and controls. The prevalence of the G/G genotype in healthy controls (45.5%) was lower than in hypertension patients (64.3%), suggesting that it might be a risk factor for the disease. PTPRD TTC genetic haplotypes were strongly linked with hypertension (P = 0.003, OR = 4.03).
CONCLUSIONS: This study provides a comprehensive understanding of the involvement of rs10739150 within the PTPRD gene in hypertension. This new knowledge could potentially transform the way we approach hypertension diagnosis, providing an accurate diagnostic tool for classifying individuals who are at a higher risk of developing this condition.
METHODS: The current study included 200 Jordanian individuals diagnosed with hypertension, compared to 224 healthy controls. Whole blood samples were drawn from each individual for DNA isolation and genotyping. The SNPStats tool was used to assess haplotype, genotype, and allele frequencies by the mean of chi-square (χ2).
RESULTS: Except for rs10739150 of PTPRD (P = 0.0003), the genotypic and allelic distribution of the SNP was identical between patients and controls. The prevalence of the G/G genotype in healthy controls (45.5%) was lower than in hypertension patients (64.3%), suggesting that it might be a risk factor for the disease. PTPRD TTC genetic haplotypes were strongly linked with hypertension (P = 0.003, OR = 4.03).
CONCLUSIONS: This study provides a comprehensive understanding of the involvement of rs10739150 within the PTPRD gene in hypertension. This new knowledge could potentially transform the way we approach hypertension diagnosis, providing an accurate diagnostic tool for classifying individuals who are at a higher risk of developing this condition.
摘要：
背景：高血压，也被称为高血压（HTN），是一种复杂的疾病，由复杂的生理过程网络控制。未经治疗的高血压与死亡率增加有关，需要了解影响高血压易感性和发展的遗传基础。当前的研究试图确定七个候选基因（NOS3，NOS1AP，REN,PLA2G4A,TCF7L,ADRB1和PTPRD）。
方法：当前的研究包括200名被诊断为高血压的约旦个体，与224名健康对照相比。从每个个体抽取全血样品用于DNA分离和基因分型。SNPStats工具用于评估单倍型，基因型，和等位基因频率的卡方平均值(χ2)。
结果：除PTPRD的rs10739150外（P=0.0003），SNP的基因型和等位基因分布在患者和对照组之间相同.健康对照者G/G基因型患病率(45.5%)低于高血压患者(64.3%),这表明它可能是这种疾病的危险因素。PTPRDTTC基因单倍型与高血压密切相关(P=0.003,OR=4.03)。
结论：本研究全面了解PTPRD基因中rs10739150参与高血压的情况。这种新知识可能会改变我们进行高血压诊断的方式，提供一种准确的诊断工具，用于对发展这种疾病风险较高的个体进行分类。
方法：当前的研究包括200名被诊断为高血压的约旦个体，与224名健康对照相比。从每个个体抽取全血样品用于DNA分离和基因分型。SNPStats工具用于评估单倍型，基因型，和等位基因频率的卡方平均值(χ2)。
结果：除PTPRD的rs10739150外（P=0.0003），SNP的基因型和等位基因分布在患者和对照组之间相同.健康对照者G/G基因型患病率(45.5%)低于高血压患者(64.3%),这表明它可能是这种疾病的危险因素。PTPRDTTC基因单倍型与高血压密切相关(P=0.003,OR=4.03)。
结论：本研究全面了解PTPRD基因中rs10739150参与高血压的情况。这种新知识可能会改变我们进行高血压诊断的方式，提供一种准确的诊断工具，用于对发展这种疾病风险较高的个体进行分类。
