Abstract：
Glioma is the most common primary intracranial tumor with high mortality and poor prognosis. The purpose of this study was to investigate how single-nucleotide polymorphisms (SNPs) of the NID2 gene affect glioma risk and prognosis. Four candidate SNPs of NID2 in 529 glioma patients and 478 healthy controls were successfully genotyped by Agena MassARRAY mass spectrometer. Logistic regression was utilized to assess the associations between NID2 SNPs and glioma risk under different genetic models. Furthermore, the relationship between risk-related SNPs in NID2 and the prognosis of glioma patients was explored through Kaplan-Meier (KM) survival curve and Cox proportional hazard regression analysis. The results showed that rs11846847 (OR 1.24, p = 0.017) and rs1874569 (OR 1.22, p = 0.026) were significantly associated with an increased risk of glioma, and rs11846847 also had a risk-increasing effect on glioma in participants ≤ 40 years old. The interaction model of rs11846847 and rs1874569 could be more suitable for forecasting glioma risk. We also discovered a significant association between rs1874569 and poor prognosis in glioma patients (HR 1.32, p = 0.039) and especially CC genotype was relevant to shorter overall survival (OS) and progression-free survival (PFS) in patients with high-grade glioma. Additionally, the study demonstrated that gross total resection or chemotherapy improve glioma prognosis in the Chinese Han population. This study is the first to provide evidence for the association of NID2 SNPs with glioma risk and prognosis, suggesting that NID2 variants might be potential factors for glioma.
摘要：
胶质瘤是颅内最常见的原发性肿瘤,死亡率高,预后差。目的探讨NID2基因单核苷酸多态性(SNPs)对胶质瘤发病风险及预后的影响。通过AgenaMassARRAY质谱仪成功对529例神经胶质瘤患者和478例健康对照中的NID2的四个候选SNP进行了基因分型。使用Logistic回归评估不同遗传模型下NID2SNP与神经胶质瘤风险之间的关联。此外，通过Kaplan-Meier(KM)生存曲线和Cox比例风险回归分析,探讨NID2中风险相关SNPs与胶质瘤患者预后的关系.结果显示,rs11846847(OR1.24,p=0.017)和rs1874569(OR1.22,p=0.026)与胶质瘤风险增加显著相关,rs11846847对≤40岁参与者的神经胶质瘤也有增加风险的作用.rs11846847和rs1874569的交互作用模型更适合预测胶质瘤的发病风险。我们还发现rs1874569与神经胶质瘤患者的不良预后之间存在显着关联（HR1.32，p=0.039），尤其是CC基因型与高患者的总生存期（OS）和无进展生存期（PFS）相关。此外,研究表明，在中国汉族人群中，大体全切除或化疗可改善胶质瘤预后。本研究首次为NID2SNPs与神经胶质瘤风险和预后的相关性提供了证据,提示NID2变异可能是神经胶质瘤的潜在因素。
