Abstract：
OBJECTIVE: There is a knowledge gap regarding long-term outcomes for males undergoing surgery for an anorectal malformation (ARM). The purpose of this study was to investigate bowel function, bladder function, and health-related quality of life (HRQoL) in male patients with an anorectal malformation.
METHODS: This cross-sectional questionnaire-based study included males treated for ARM at our institution between 1994 and 2017. Bowel function was assessed with bowel function score (BFS) while urinary tract function was assessed with lower urinary tract symptoms (LUTS) questionnaires. Health-related quality of life (HRQoL) was investigated using age-relevant questionnaires (KIDSCREEN and PGWBI). Patient characteristics were retrospectively collected from the medical records and descriptive statistics were used for analysis. Functional outcomes were compared with gender and age-matched controls while HRQoL was compared to normative data. The study was approved by ethics review authorities.
RESULTS: A total of 58 (44.6%) of 130 males responded to the questionnaires. Regarding bowel function, 24 (42.1%) of 57 patients and 81 (95.3%) of 85 controls, respectively, reported a well-preserved bowel function represented by a BFS ≥ 17 (p < 0.001). Soiling issues and \'feels urge\' items improved significantly with age. In a linear regression model, BFS increased significantly with age. For most parameters, the proportion of ARM patients with lower urinary tract symptoms was larger, though not significantly, compared to the controls. However, straining and stress incontinence were reported significantly more often by ARM patients. In patients and controls, voiding outcomes in terms of prevalence of having symptoms and the number of cumulative symptoms drop with increasing age. Children and adults reported similar or, in some domains, better HRQoL outcomes when compared to normative European data.
CONCLUSIONS: Bowel function is impaired in male patients with ARM but significantly improves with age. Urinary tract function was affected, but overall comparable to the controls. HRQoL was unaffected. No significant association between the studied outcomes could be shown.
METHODS: III.
METHODS: This cross-sectional questionnaire-based study included males treated for ARM at our institution between 1994 and 2017. Bowel function was assessed with bowel function score (BFS) while urinary tract function was assessed with lower urinary tract symptoms (LUTS) questionnaires. Health-related quality of life (HRQoL) was investigated using age-relevant questionnaires (KIDSCREEN and PGWBI). Patient characteristics were retrospectively collected from the medical records and descriptive statistics were used for analysis. Functional outcomes were compared with gender and age-matched controls while HRQoL was compared to normative data. The study was approved by ethics review authorities.
RESULTS: A total of 58 (44.6%) of 130 males responded to the questionnaires. Regarding bowel function, 24 (42.1%) of 57 patients and 81 (95.3%) of 85 controls, respectively, reported a well-preserved bowel function represented by a BFS ≥ 17 (p < 0.001). Soiling issues and \'feels urge\' items improved significantly with age. In a linear regression model, BFS increased significantly with age. For most parameters, the proportion of ARM patients with lower urinary tract symptoms was larger, though not significantly, compared to the controls. However, straining and stress incontinence were reported significantly more often by ARM patients. In patients and controls, voiding outcomes in terms of prevalence of having symptoms and the number of cumulative symptoms drop with increasing age. Children and adults reported similar or, in some domains, better HRQoL outcomes when compared to normative European data.
CONCLUSIONS: Bowel function is impaired in male patients with ARM but significantly improves with age. Urinary tract function was affected, but overall comparable to the controls. HRQoL was unaffected. No significant association between the studied outcomes could be shown.
METHODS: III.
摘要：
目的：对于接受肛门直肠畸形（ARM）手术的男性患者的长期预后存在知识差距。这项研究的目的是调查肠道功能，膀胱功能,男性肛门直肠畸形患者的健康相关生活质量（HRQoL）。
方法：这项基于横断面问卷的研究包括1994年至2017年在我们机构接受ARM治疗的男性。用肠功能评分（BFS）评估肠功能，用下尿路症状（LUTS）问卷评估尿路功能。使用年龄相关问卷（KIDSCREEN和PGWBI）调查与健康相关的生活质量（HRQoL）。从病历中回顾性收集患者特征，并使用描述性统计进行分析。将功能结果与性别和年龄匹配的对照进行比较，而将HRQoL与规范数据进行比较。该研究得到了伦理审查机构的批准。
结果：130名男性中有58名（44.6%）回答了问卷。关于肠道功能，57例患者中有24例（42.1％），85例对照中有81例（95.3％），分别,报道了以BFS≥17为代表的良好肠道功能（p<0.001）。随着年龄的增长，污染问题和“感觉冲动”项目显着改善。在线性回归模型中，BFS随年龄显著增加。对于大多数参数，ARM患者中出现下尿路症状的比例较大,虽然不重要，与对照组相比。然而,ARM患者报告的紧张和压力性尿失禁的频率明显更高。在患者和对照组中，根据有症状的患病率和累积症状数量,排尿结局随年龄增长而下降.儿童和成人报告类似或，在某些领域，与欧洲规范数据相比，HRQoL结果更好。
结论：男性ARM患者的肠功能受损，但随着年龄的增长而显著改善。尿路功能受到影响，但总体上与对照组相当。HRQoL未受影响。研究结果之间没有显着关联。
方法：III.
方法：这项基于横断面问卷的研究包括1994年至2017年在我们机构接受ARM治疗的男性。用肠功能评分（BFS）评估肠功能，用下尿路症状（LUTS）问卷评估尿路功能。使用年龄相关问卷（KIDSCREEN和PGWBI）调查与健康相关的生活质量（HRQoL）。从病历中回顾性收集患者特征，并使用描述性统计进行分析。将功能结果与性别和年龄匹配的对照进行比较，而将HRQoL与规范数据进行比较。该研究得到了伦理审查机构的批准。
结果：130名男性中有58名（44.6%）回答了问卷。关于肠道功能，57例患者中有24例（42.1％），85例对照中有81例（95.3％），分别,报道了以BFS≥17为代表的良好肠道功能（p<0.001）。随着年龄的增长，污染问题和“感觉冲动”项目显着改善。在线性回归模型中，BFS随年龄显著增加。对于大多数参数，ARM患者中出现下尿路症状的比例较大,虽然不重要，与对照组相比。然而,ARM患者报告的紧张和压力性尿失禁的频率明显更高。在患者和对照组中，根据有症状的患病率和累积症状数量,排尿结局随年龄增长而下降.儿童和成人报告类似或，在某些领域，与欧洲规范数据相比，HRQoL结果更好。
结论：男性ARM患者的肠功能受损，但随着年龄的增长而显著改善。尿路功能受到影响，但总体上与对照组相当。HRQoL未受影响。研究结果之间没有显着关联。
方法：III.
