Abstract：
BACKGROUND: A primary palliative care model for cystic fibrosis (CF) recommends using the Integrated Palliative Care Outcome Scale (IPOS) for screening. Validation of the IPOS is needed.
METHODS: This secondary analysis utilized baseline data from a multisite trial of the palliative care model, Improving Life with CF. Adults with CF completed the IPOS, the Memorial Symptom Assessment Scale-CF (MSAS-CF), the CF Questionnaire-Revised (CFQ-R), the Patient Health Questionnaire (PHQ-8), the Generalized Anxiety Disorder (GAD-7), and the Perceived Stress Scale (PSS). IPOS structure was assessed using Cronbach α coefficients and a factor analysis. Construct validity was evaluated through bivariate relationships between IPOS scores and other questionnaire scores, and linear regressions assessing the extent to which the IPOS explains variance in quality-of-life domains.
RESULTS: The sample comprised 256 adults with complete IPOS data. α coefficients were .86 for the IPOS total score, .81 for the Physical Symptoms subscale, .79 for the Emotional Symptoms subscale, and .63 for the Communication/Practical Issues subscale. A two-component factor structure best aligned with the current subscales. IPOS scores were significantly associated with other measures; associations with MSAS-CF and CFQ-R subscales differentiated the IPOS Physical and Emotional subscales. The IPOS total score provided unique information about the variance in the CFQ-R Physical Functioning and Respiratory Symptoms domain scores.
CONCLUSIONS: In adults with CF, the IPOS has acceptable internal consistency and there is evidence of construct validity. These findings support adoption of the IPOS in the primary palliative care model for CF.
METHODS: This secondary analysis utilized baseline data from a multisite trial of the palliative care model, Improving Life with CF. Adults with CF completed the IPOS, the Memorial Symptom Assessment Scale-CF (MSAS-CF), the CF Questionnaire-Revised (CFQ-R), the Patient Health Questionnaire (PHQ-8), the Generalized Anxiety Disorder (GAD-7), and the Perceived Stress Scale (PSS). IPOS structure was assessed using Cronbach α coefficients and a factor analysis. Construct validity was evaluated through bivariate relationships between IPOS scores and other questionnaire scores, and linear regressions assessing the extent to which the IPOS explains variance in quality-of-life domains.
RESULTS: The sample comprised 256 adults with complete IPOS data. α coefficients were .86 for the IPOS total score, .81 for the Physical Symptoms subscale, .79 for the Emotional Symptoms subscale, and .63 for the Communication/Practical Issues subscale. A two-component factor structure best aligned with the current subscales. IPOS scores were significantly associated with other measures; associations with MSAS-CF and CFQ-R subscales differentiated the IPOS Physical and Emotional subscales. The IPOS total score provided unique information about the variance in the CFQ-R Physical Functioning and Respiratory Symptoms domain scores.
CONCLUSIONS: In adults with CF, the IPOS has acceptable internal consistency and there is evidence of construct validity. These findings support adoption of the IPOS in the primary palliative care model for CF.
摘要：
背景：囊性纤维化（CF）的主要姑息治疗模式建议使用综合姑息治疗结果量表（IPOS）进行筛查。需要对IPOS进行验证。
方法：这项次要分析利用了姑息治疗模式的多中心试验的基线数据，使用CF改善寿命。患有CF的成年人完成了IPOS，纪念症状评估量表-CF(MSAS-CF)，CF问卷修订(CFQ-R)，患者健康问卷（PHQ-8），广泛性焦虑症（GAD-7），和感知压力量表(PSS)。使用Cronbachα系数和因子分析评估IPOS结构。通过IPOS得分和其他问卷得分之间的双变量关系来评估结构效度，和线性回归评估IPOS解释生活质量领域差异的程度。
结果：样本包括256名具有完整IPOS数据的成年人。IPOS总分的α系数为0.86，.81为身体症状分量表，.79为情绪症状分量表，通信/实际问题分量表。两分量因子结构与当前子量表最佳匹配。IPOS评分与其他指标显着相关；与MSAS-CF和CFQ-R分量表的关联区分了IPOS身体和情绪分量表。IPOS总分提供了关于CFQ-R身体功能和呼吸症状领域得分差异的独特信息。
结论：在患有CF的成年人中，IPOS具有可接受的内部一致性，并且有结构效度的证据。这些发现支持在CF的主要姑息治疗模式中采用IPOS。
方法：这项次要分析利用了姑息治疗模式的多中心试验的基线数据，使用CF改善寿命。患有CF的成年人完成了IPOS，纪念症状评估量表-CF(MSAS-CF)，CF问卷修订(CFQ-R)，患者健康问卷（PHQ-8），广泛性焦虑症（GAD-7），和感知压力量表(PSS)。使用Cronbachα系数和因子分析评估IPOS结构。通过IPOS得分和其他问卷得分之间的双变量关系来评估结构效度，和线性回归评估IPOS解释生活质量领域差异的程度。
结果：样本包括256名具有完整IPOS数据的成年人。IPOS总分的α系数为0.86，.81为身体症状分量表，.79为情绪症状分量表，通信/实际问题分量表。两分量因子结构与当前子量表最佳匹配。IPOS评分与其他指标显着相关；与MSAS-CF和CFQ-R分量表的关联区分了IPOS身体和情绪分量表。IPOS总分提供了关于CFQ-R身体功能和呼吸症状领域得分差异的独特信息。
结论：在患有CF的成年人中，IPOS具有可接受的内部一致性，并且有结构效度的证据。这些发现支持在CF的主要姑息治疗模式中采用IPOS。
