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Abstract：
OBJECTIVE: Asthma, a chronic inflammatory disease with diverse pathomechanisms, presents challenges in developing personalized diagnostic and therapeutic approaches. This review aims to provide a comprehensive overview of the role of exosomes, small extracellular vesicles, in asthma pathophysiology and explores their potential as diagnostic biomarkers and therapeutic tools.
METHODS: A literature search was conducted to identify recent studies investigating the involvement of exosomes in asthma. The retrieved articles were analyzed to extract relevant information on the role of exosomes in maintaining lung microenvironment homeostasis, regulating inflammatory responses, and their diagnostic and therapeutic potential for asthma.
RESULTS: Exosomes secreted by various cell types, have emerged as crucial mediators of intercellular communication in healthy and diseased conditions. Evidence suggest that exosomes play a significant role in maintaining lung microenvironment homeostasis and contribute to asthma pathogenesis by regulating inflammatory responses. Differential exosomal content between healthy individuals and asthmatics holds promise for the development of novel asthma biomarkers. Furthermore, exosomes secreted by immune and nonimmune cells, as well as those detected in biofluids, demonstrate potential in promoting or regulating immune responses, making them attractive candidates for designing new treatment strategies for inflammatory conditions such as asthma.
CONCLUSIONS: Exosomes, with their ability to modulate immune responses and deliver therapeutic cargo, offer potential as targeted therapeutic tools in asthma management. Further research and clinical trials are required to fully understand the mechanisms underlying exosome-mediated effects and translate these findings into effective diagnostic and therapeutic strategies for asthma patients.
METHODS: A literature search was conducted to identify recent studies investigating the involvement of exosomes in asthma. The retrieved articles were analyzed to extract relevant information on the role of exosomes in maintaining lung microenvironment homeostasis, regulating inflammatory responses, and their diagnostic and therapeutic potential for asthma.
RESULTS: Exosomes secreted by various cell types, have emerged as crucial mediators of intercellular communication in healthy and diseased conditions. Evidence suggest that exosomes play a significant role in maintaining lung microenvironment homeostasis and contribute to asthma pathogenesis by regulating inflammatory responses. Differential exosomal content between healthy individuals and asthmatics holds promise for the development of novel asthma biomarkers. Furthermore, exosomes secreted by immune and nonimmune cells, as well as those detected in biofluids, demonstrate potential in promoting or regulating immune responses, making them attractive candidates for designing new treatment strategies for inflammatory conditions such as asthma.
CONCLUSIONS: Exosomes, with their ability to modulate immune responses and deliver therapeutic cargo, offer potential as targeted therapeutic tools in asthma management. Further research and clinical trials are required to fully understand the mechanisms underlying exosome-mediated effects and translate these findings into effective diagnostic and therapeutic strategies for asthma patients.
摘要：
目的：哮喘，一种具有不同病理机制的慢性炎症性疾病，在开发个性化诊断和治疗方法方面提出了挑战。这篇综述旨在全面概述外泌体的作用，小的细胞外囊泡，并探索其作为诊断生物标志物和治疗工具的潜力。
方法：进行了文献检索，以确定研究外泌体与哮喘的关系的最新研究。对检索到的文章进行分析，以提取有关外泌体在维持肺微环境稳态中的作用的相关信息。调节炎症反应，以及它们对哮喘的诊断和治疗潜力。
结果：由各种细胞类型分泌的外泌体，已成为健康和患病条件下细胞间通讯的关键介质。证据表明，外泌体在维持肺微环境稳态中起重要作用，并通过调节炎症反应促进哮喘的发病机理。健康个体和哮喘患者之间的外泌体含量差异有望开发新的哮喘生物标志物。此外，免疫细胞和非免疫细胞分泌的外泌体，以及在生物流体中检测到的那些，表现出促进或调节免疫反应的潜力，使他们有吸引力的候选人设计新的治疗策略，如哮喘。
结论：外泌体，具有调节免疫反应和提供治疗性货物的能力，在哮喘管理中提供作为靶向治疗工具的潜力。需要进一步的研究和临床试验来充分了解外泌体介导作用的潜在机制，并将这些发现转化为哮喘患者的有效诊断和治疗策略。
方法：进行了文献检索，以确定研究外泌体与哮喘的关系的最新研究。对检索到的文章进行分析，以提取有关外泌体在维持肺微环境稳态中的作用的相关信息。调节炎症反应，以及它们对哮喘的诊断和治疗潜力。
结果：由各种细胞类型分泌的外泌体，已成为健康和患病条件下细胞间通讯的关键介质。证据表明，外泌体在维持肺微环境稳态中起重要作用，并通过调节炎症反应促进哮喘的发病机理。健康个体和哮喘患者之间的外泌体含量差异有望开发新的哮喘生物标志物。此外，免疫细胞和非免疫细胞分泌的外泌体，以及在生物流体中检测到的那些，表现出促进或调节免疫反应的潜力，使他们有吸引力的候选人设计新的治疗策略，如哮喘。
结论：外泌体，具有调节免疫反应和提供治疗性货物的能力，在哮喘管理中提供作为靶向治疗工具的潜力。需要进一步的研究和临床试验来充分了解外泌体介导作用的潜在机制，并将这些发现转化为哮喘患者的有效诊断和治疗策略。
