PDF(Pubmed)
Abstract：
UNASSIGNED: Epidemiological studies show dietary habits can have an impact on the risk of cholelithiasis, but the relationship is still unclear. We used a comprehensive Mendelian randomization (MR) study to explore the relationship between dietary habits and cholelithiasis.
UNASSIGNED: The 18 dietary habits were divided into six categories: meat foods, cereals, vegetables, fruits, dairy products, beverages, and condiments. Cholelithiasis data came from a GWAS meta-analysis and the FinnGen consortium. The inverse variance weighted (IVW), the weighted median (WM), and MR-Egger approaches were used as the main MR analysis methods. In addition, multiple sensitivity analysis and meta-analysis were performed to verify the robustness of the results.
UNASSIGNED: Dried fruit intake [odds ratio (OR) = 0.568; 95% confidence interval (CI), 0.405-0.797; p = 0.001] was discovered to reduce the risk of cholelithiasis. The sensitivity analysis and meta-analysis showed reliable results for the relationship between dried fruit intake and cholelithiasis.
UNASSIGNED: Our study found that dried fruit intake is a protective factor in the development of cholelithiasis. However, the mechanisms of action need to be further explored.
UNASSIGNED: The 18 dietary habits were divided into six categories: meat foods, cereals, vegetables, fruits, dairy products, beverages, and condiments. Cholelithiasis data came from a GWAS meta-analysis and the FinnGen consortium. The inverse variance weighted (IVW), the weighted median (WM), and MR-Egger approaches were used as the main MR analysis methods. In addition, multiple sensitivity analysis and meta-analysis were performed to verify the robustness of the results.
UNASSIGNED: Dried fruit intake [odds ratio (OR) = 0.568; 95% confidence interval (CI), 0.405-0.797; p = 0.001] was discovered to reduce the risk of cholelithiasis. The sensitivity analysis and meta-analysis showed reliable results for the relationship between dried fruit intake and cholelithiasis.
UNASSIGNED: Our study found that dried fruit intake is a protective factor in the development of cholelithiasis. However, the mechanisms of action need to be further explored.
摘要：
■流行病学研究表明，饮食习惯可以影响胆石症的风险，但是这种关系还不清楚。我们使用了一项全面的孟德尔随机（MR）研究来探讨饮食习惯与胆石症之间的关系。
■18种饮食习惯分为6类：肉类食品，谷物,蔬菜,水果,乳制品,饮料,和调味品。胆石病数据来自GWAS荟萃分析和FinnGen联盟。逆方差加权(IVW)，加权中位数(WM)，MR-Egger方法被用作主要的MR分析方法。此外,进行了多敏感性分析和荟萃分析以验证结果的稳健性.
■干果摄入量[比值比（OR）=0.568；95％置信区间（CI），0.405-0.797;p=0.001]被发现可以降低胆石症的风险。敏感性分析和荟萃分析显示了干果摄入量与胆石症之间关系的可靠结果。
■我们的研究发现，干果摄入量是胆石症发展的保护因素。然而,行动机制需要进一步探索。
■18种饮食习惯分为6类：肉类食品，谷物,蔬菜,水果,乳制品,饮料,和调味品。胆石病数据来自GWAS荟萃分析和FinnGen联盟。逆方差加权(IVW)，加权中位数(WM)，MR-Egger方法被用作主要的MR分析方法。此外,进行了多敏感性分析和荟萃分析以验证结果的稳健性.
■干果摄入量[比值比（OR）=0.568；95％置信区间（CI），0.405-0.797;p=0.001]被发现可以降低胆石症的风险。敏感性分析和荟萃分析显示了干果摄入量与胆石症之间关系的可靠结果。
■我们的研究发现，干果摄入量是胆石症发展的保护因素。然而,行动机制需要进一步探索。
