{Reference Type}: Journal Article
{Title}: The causal relationship between diet habits and cholelithiasis: a comprehensive Mendelian randomization (MR) study.
{Author}: Xie L;Xu M;Lei Y;Li J;Xie J;
{Journal}: Front Nutr
{Volume}: 11
{Issue}: 0
{Year}: 2024
{Factor}: 6.59
{DOI}: 10.3389/fnut.2024.1377631
{Abstract}: <B>UNASSIGNED: </B>Epidemiological studies show dietary habits can have an impact on the risk of cholelithiasis, but the relationship is still unclear. We used a comprehensive Mendelian randomization (MR) study to explore the relationship between dietary habits and cholelithiasis.<BR><B>UNASSIGNED: </B>The 18 dietary habits were divided into six categories: meat foods, cereals, vegetables, fruits, dairy products, beverages, and condiments. Cholelithiasis data came from a GWAS meta-analysis and the FinnGen consortium. The inverse variance weighted (IVW), the weighted median (WM), and MR-Egger approaches were used as the main MR analysis methods. In addition, multiple sensitivity analysis and meta-analysis were performed to verify the robustness of the results.<BR><B>UNASSIGNED: </B>Dried fruit intake [odds ratio (OR) = 0.568; 95% confidence interval (CI), 0.405-0.797; p = 0.001] was discovered to reduce the risk of cholelithiasis. The sensitivity analysis and meta-analysis showed reliable results for the relationship between dried fruit intake and cholelithiasis.<BR><B>UNASSIGNED: </B>Our study found that dried fruit intake is a protective factor in the development of cholelithiasis. However, the mechanisms of action need to be further explored.