PDF(Pubmed)
Abstract：
Emerging evidence has highlighted the capacity of hematogenous cells in skull and vertebral bone marrow to enter the meningeal borders via ossified vascular channels and maintain immune homeostasis in the central nervous system (CNS). CNS-adjacent skull and vertebral bone marrow comprises hematopoietic niches that can sense CNS injury and supply specialized immune cells to fine-tune inflammatory responses. Here, we review recent advances in our understanding of skull and vertebral bone marrow-derived immune cells in homeostasis and inflammatory CNS diseases. Further, we discuss the implications for future development of therapies to mitigate CNS inflammation and its detrimental sequelae in neurological disorders.
摘要：
新出现的证据强调了颅骨和椎骨骨髓中的血源性细胞通过骨化的血管通道进入脑膜边界并维持中枢神经系统（CNS）的免疫稳态的能力。与CNS相邻的颅骨和椎骨骨髓包含造血生态位，可以感知CNS损伤并提供专门的免疫细胞以微调炎症反应。这里,我们回顾了我们对颅骨和椎体骨髓来源的免疫细胞在稳态和炎症性中枢神经系统疾病中的最新进展。Further,我们讨论了减轻中枢神经系统炎症及其在神经系统疾病中的有害后遗症的疗法对未来发展的意义。
