PDF(Pubmed)
Abstract：
Squamous cell carcinoma (SCC) is a prevalent malignancy affecting multiple organs in the human body, including the oral cavity, esophagus, cervix, and skin. Given its significant incidence and mortality rates, researchers are actively seeking effective diagnostic and therapeutic strategies. In recent years, exosomes and their molecular cargo, particularly circular RNA (circRNA), have emerged as promising areas of investigation in SCC research. Exosomes are small vesicles released into the extracellular environment by cells that contain biomolecules that reflect the physiological state of the cell of origin. CircRNAs, known for their unique covalently closed loop structure and stability, have garnered special attention in oncology and are closely associated with tumorigenesis, progression, metastasis, and drug resistance. Interestingly, exosomal circRNAs have been identified as ideal biomarkers for noninvasive cancer diagnosis and prognosis assessment. This article reviews the progress in research on exosomal circRNAs, focusing on their expression patterns, functions, and potential applications as biomarkers in SCC, aiming to provide new insights and strategies for the diagnosis and treatment of SCC.
摘要：
鳞状细胞癌（SCC）是影响人体多个器官的常见恶性肿瘤，包括口腔，食道,子宫颈,和皮肤。鉴于其显著的发病率和死亡率，研究人员正在积极寻求有效的诊断和治疗策略.近年来,外泌体和它们的分子货物，特别是环状RNA(circularRNA)，已成为SCC研究的有希望的研究领域。外来体是由含有反映起源细胞的生理状态的生物分子的细胞释放到细胞外环境中的小囊泡。CircRNAs,以其独特的共价闭环结构和稳定性而闻名，在肿瘤学中受到特别关注，并且与肿瘤发生密切相关，programming,转移,和抗药性。有趣的是,外泌体circRNAs已被确定为非侵入性癌症诊断和预后评估的理想生物标志物。本文综述了外泌体circRNAs的研究进展,专注于他们的表达方式，功能,以及作为SCC生物标志物的潜在应用，旨在为SCC的诊断和治疗提供新的见解和策略。
