PDF(Pubmed)
Abstract：
UNASSIGNED: We aimed to investigate the association between coffee drinking and total caffeine intakes with the chance of prediabetes (Pre-DM) regression and progression over 9-years of follow-up.
UNASSIGNED: This cohort study included 334 Pre-DM individuals (mean age of 49.4 ± 12.8 years and 51.5% men) who participated in the third phase of the Tehran Lipid and Glucose Study (2006-2008). A validated food frequency questionnaire at baseline assessed habitual coffee consumption. All measurements were done at baseline and all subsequent examinations with 3-year follow-up intervals. The odds ratios (OR) and 95% confidence intervals (CIs) of Pre-DM regression to normal glycemia or progression to type 2 diabetes (T2D) in coffee drinkers/non-drinkers were estimated using multinomial logistic regression analysis.
UNASSIGNED: During the study follow-up 39.8% of the study participants were progressed to T2D and 39.8% returned to normal glycemia. Coffee consumption nearly doubled the chance of returning to normal (OR = 2.26, 95% CI = 1.03-4.97). Total caffeine intake was not related to Pre-DM progression and regression. Compared to non-drinkers, coffee drinkers had significantly lower 2-hour serum glucose concentrations over time (152, 95% CI = 144-159 vs. 162, 95% CI = 155-169 mg/dL, P = 0.05).
UNASSIGNED: Habitual coffee drinking may increase the chance of returning to normal glycemia in Pre-DM subjects.
UNASSIGNED: This cohort study included 334 Pre-DM individuals (mean age of 49.4 ± 12.8 years and 51.5% men) who participated in the third phase of the Tehran Lipid and Glucose Study (2006-2008). A validated food frequency questionnaire at baseline assessed habitual coffee consumption. All measurements were done at baseline and all subsequent examinations with 3-year follow-up intervals. The odds ratios (OR) and 95% confidence intervals (CIs) of Pre-DM regression to normal glycemia or progression to type 2 diabetes (T2D) in coffee drinkers/non-drinkers were estimated using multinomial logistic regression analysis.
UNASSIGNED: During the study follow-up 39.8% of the study participants were progressed to T2D and 39.8% returned to normal glycemia. Coffee consumption nearly doubled the chance of returning to normal (OR = 2.26, 95% CI = 1.03-4.97). Total caffeine intake was not related to Pre-DM progression and regression. Compared to non-drinkers, coffee drinkers had significantly lower 2-hour serum glucose concentrations over time (152, 95% CI = 144-159 vs. 162, 95% CI = 155-169 mg/dL, P = 0.05).
UNASSIGNED: Habitual coffee drinking may increase the chance of returning to normal glycemia in Pre-DM subjects.
摘要：
■我们的目的是调查咖啡饮用和总咖啡因摄入量与9年随访期间前驱糖尿病（Pre-DM）消退和进展的可能性之间的关系。
该队列研究包括334名参加德黑兰脂质和葡萄糖研究第三阶段（2006-2008）的DM前个体（平均年龄49.4±12.8岁，男性占51.5％）。基线时经过验证的食物频率问卷评估了习惯性咖啡消费。所有测量均在基线时进行，所有后续检查均以3年的随访间隔进行。使用多项逻辑回归分析估计了饮用咖啡/不饮用咖啡的人中Pre-DM回归到正常血糖或进展为2型糖尿病（T2D）的比值比（OR）和95％置信区间（CI）。
■在研究随访期间，39.8%的研究参与者进展到T2D，39.8%的参与者恢复正常血糖。咖啡消费恢复正常的机会几乎增加了一倍（OR=2.26，95％CI=1.03-4.97）。总咖啡因摄入量与DM前进展和消退无关。与不喝酒的人相比，随着时间的推移，喝咖啡的人2小时血清葡萄糖浓度显着降低(152，95%CI=144-159vs.162，95%CI=155-169mg/dL，P=0.05)。
■习惯性饮用咖啡可能会增加DM前受试者恢复正常血糖的机会。
该队列研究包括334名参加德黑兰脂质和葡萄糖研究第三阶段（2006-2008）的DM前个体（平均年龄49.4±12.8岁，男性占51.5％）。基线时经过验证的食物频率问卷评估了习惯性咖啡消费。所有测量均在基线时进行，所有后续检查均以3年的随访间隔进行。使用多项逻辑回归分析估计了饮用咖啡/不饮用咖啡的人中Pre-DM回归到正常血糖或进展为2型糖尿病（T2D）的比值比（OR）和95％置信区间（CI）。
■在研究随访期间，39.8%的研究参与者进展到T2D，39.8%的参与者恢复正常血糖。咖啡消费恢复正常的机会几乎增加了一倍（OR=2.26，95％CI=1.03-4.97）。总咖啡因摄入量与DM前进展和消退无关。与不喝酒的人相比，随着时间的推移，喝咖啡的人2小时血清葡萄糖浓度显着降低(152，95%CI=144-159vs.162，95%CI=155-169mg/dL，P=0.05)。
■习惯性饮用咖啡可能会增加DM前受试者恢复正常血糖的机会。
