Abstract：
Malaria has been one of the most lethal infectious diseases throughout history, claiming a high number of human lives. The genomic plasticity of Plasmodium falciparum, the causative agent of the most severe and deadly form of malaria, gives the parasite a constant resistance to drugs developed for its control. Despite efforts to control and even eradicate the disease, these have largely been unsuccessful due to the parasite\'s continuous adaptations. This study aims to examine the key genes involved in parasite resistance and propose a shift in the combat strategy. Gene silencing techniques offer promise in combating malaria, yet further research is needed to harness their potential for disease control fully. Although there is still a long way to go for the implementation of gene silencing-based therapeutic strategies, this review addresses examples of the use of such techniques in various human diseases and how they could be extrapolated for malaria treatment.
摘要：
疟疾是历史上最致命的传染病之一,夺去了大量的生命。恶性疟原虫的基因组可塑性，最严重和最致命的疟疾的病原体，使寄生虫对开发用于控制其的药物具有恒定的抵抗力。尽管努力控制甚至根除这种疾病，由于寄生虫的持续适应，这些方法在很大程度上是不成功的。这项研究旨在研究与寄生虫抗性有关的关键基因，并提出战斗策略的转变。基因沉默技术为抗击疟疾提供了希望，然而，还需要进一步的研究来充分利用他们的潜力来控制疾病。尽管实施基于基因沉默的治疗策略还有很长的路要走，这篇综述讨论了在各种人类疾病中使用此类技术的例子，以及如何将其推断为疟疾治疗。
