PDF(Pubmed)
Abstract：
Infectious pancreatic necrosis virus (IPNV) causes economic losses with a highly variable mortality rate worldwide, especially in rainbow trout. The virus has a double-stranded bi-partite RNA genome designated segment A and B. New complete genome sequences of nine rainbow trout isolates from Turkey were determined and subjected to phylogenetic analysis, identifying all as genotype 5 (serotype Sp). A time-dependent change in the extended pathogenicity motif of VP2 from P217T221A247 (PTA) to PTE P217T221E247 over a period of 10 years was identified. A wider analysis of 99 IPNV sequences from Turkey and Iran revealed the emergence of the motif PTE from 2007 to 2017, inducing significant morbidity in fry by 2013. In fact, displacement of the PTA motif, by the PTE motif in IPNV isolates appeared to be connected to a production peak of rainbow trout in 2013. An additional CAI analysis provided more evidence, indicating that rainbow trout culture in Turkey has an influence on the evolution of IPNV.
摘要：
传染性胰腺坏死病毒（IPNV）在全球范围内造成经济损失，死亡率差异很大。尤其是虹鳟鱼.该病毒具有双链双链RNA基因组，称为A和B段。确定了来自土耳其的9个虹鳟鱼分离株的新完整基因组序列，并进行了系统发育分析，鉴定全部为基因型5(血清型Sp)。在10年的时间内，确定了VP2从P217T221A247（PTA）到PTEP217T221E247的扩展致病性基序的时间依赖性变化。对来自土耳其和伊朗的99个IPNV序列的更广泛分析显示，从2007年到2017年出现了PTE的主题，到2013年在鱼苗中引起了显着的发病率。事实上,PTA基序的位移，IPNV分离株中的PTE基序似乎与2013年虹鳟鱼的生产高峰有关。额外的CAI分析提供了更多的证据，这表明土耳其的虹鳟鱼文化对IPNV的演变有影响。
