PDF(Pubmed)
Abstract：
This study analyzed the neurological manifestation profiles of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection across pandemic waves in pediatric patients. The study collected data on patients aged between 0 and 18 years, diagnosed with acute SARS-CoV-2 infection, admitted to a pediatric tertiary hospital between 1 March 2020 and 28 February 2023. This study included 1677 patients. Neurological manifestations were noted in 10% (n = 168) of patients with a median age of 3.2 years (interquartile range: 1-11.92). Neurological manifestations were significantly associated with the pandemic waves (p = 0.006) and age groups (p < 0.001). Seizures were noted in 4.2% of cases and reached an increasing frequency over time (p = 0.001), but were not associated with age groups. Febrile seizures accounted for the majority of seizures. Headache was reported in 2.6% of cases and had similar frequencies across the pandemic waves and age groups. Muscular involvement was noted in 2% of cases, reached a decreasing frequency over time (p < 0.001), and showed different frequencies among the age groups. Neurological manifestations of acute SARS-CoV-2 infection exhibit distinct patterns, depending on the pandemic wave and patient age group. The Wuhan and Omicron waves involved the nervous system more often than the other waves.
摘要：
这项研究分析了儿科患者大流行波中严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染的神经系统表现。该研究收集了0至18岁患者的数据，诊断为急性SARS-CoV-2感染，2020年3月1日至2023年2月28日期间入住儿科三级医院。这项研究包括1677名患者。在10％（n=168）的中位年龄为3.2岁（四分位距：1-11.92）的患者中发现了神经系统表现。神经系统表现与大流行波（p=0.006）和年龄组（p<0.001）显着相关。在4.2%的病例中发现癫痫发作，并随着时间的推移达到增加的频率(p=0.001)，但与年龄组无关。高热惊厥占癫痫发作的大多数。在2.6%的病例中报告了头痛，在大流行波和年龄组中的频率相似。在2％的病例中注意到肌肉受累，随着时间的推移达到降低的频率(p<0.001)，并在各年龄组中表现出不同的频率。急性SARS-CoV-2感染的神经系统表现表现出不同的模式，取决于大流行浪潮和患者年龄段。武汉和Omicron波比其他波更频繁地涉及神经系统。
