PDF(Pubmed)
Abstract：
TRPV1 channels are polymodal cation channels located predominantly on primary afferent neurons that are activated by inflammatory mediators, capsaicin (the active component in chili peppers), and noxious heat. TRPV1 channel antagonists are potential new analgesic agents, but their development has been hindered by the finding that they also produce loss of thermal homeostasis and response to noxious heat. Results from recent studies of the TRPV1 channel indicate that it might be possible to develop TRPV1 channel antagonists that inhibit pain without affecting noxious heat sensation. TRPV1 channels are also present in the central nervous system (CNS) and have been implicated in learning, memory, and behaviour. TRPV1 channel modulators have been proposed to have possible therapeutic potential in the treatment of neurological and psychiatric conditions. However, further understanding of the role of TRPV1 channels in the CNS is required before therapeutic advances in the treatment of neuropsychiatric conditions with TRPV1 channel modulators can be made.
摘要：
TRPV1通道是多模态阳离子通道，主要位于由炎症介质激活的初级传入神经元，辣椒素（辣椒中的活性成分），和有害的热量。TRPV1通道拮抗剂是潜在的新型镇痛剂，但是发现它们也会产生热稳态损失和对有害热的反应，从而阻碍了它们的发展。最近对TRPV1通道的研究结果表明，有可能开发出抑制疼痛而不影响有害热感的TRPV1通道拮抗剂。TRPV1通道也存在于中枢神经系统（CNS）中，并且与学习有关，记忆,和行为。已经提出TRPV1通道调节剂在治疗神经和精神病症中具有可能的治疗潜力。然而,在使用TRPV1通道调节剂治疗神经精神疾病的治疗方面取得进展之前,需要进一步了解TRPV1通道在CNS中的作用.
