PDF(Pubmed)
Abstract：
The aim of this review is to present the potential application of camphor-a bicyclic monoterpene ketone-in the prevention of skin infections. Skin diseases represent a heterogeneous group of disorders characterized by prolonged symptoms that significantly diminish the quality of life. They affect the dermis, the epidermis, and even subcutaneous tissue. They very often have a bacterial or fungal background. Therapy for dermatological skin disorders is difficult and long-term. Therefore, it is important to find a compound, preferably of natural origin, that (i) prevents the initiation of this infection and (ii) supports the skin\'s repair process. Based on its documented anti-inflammatory, antibacterial, antifungal, anti-acne, anesthetic, strengthening, and warming properties, camphor can be used as a preventative measure in dermatological infectious diseases and as a component in medical and cosmetic products. This work discusses the structure and physicochemical properties of camphor, its occurrence, and methods of obtaining it from natural sources as well as through chemical synthesis. The use of camphor in industrial preparations is also presented. Additionally, after a detailed review of the literature, the metabolism of camphor, its interactions with other medicinal substances, and its antimicrobial properties against bacteria and fungi involved in skin diseases are discussed with regard to their resistance.
摘要：
这篇综述的目的是介绍樟脑-双环单萜酮在预防皮肤感染中的潜在应用。皮肤病代表一组异质性疾病,其特征在于显著降低生活质量的延长症状。它们影响真皮，表皮，甚至是皮下组织.它们通常具有细菌或真菌背景。皮肤病学皮肤病的治疗是困难和长期的。因此,找到一个化合物很重要，最好是天然来源的，（i）防止这种感染的开始和（ii）支持皮肤的修复过程。根据其记录的抗炎作用，抗菌，抗真菌药,抗痤疮,麻醉剂,加强,和变暖特性，樟脑可用作皮肤传染病的预防措施，也可用作医疗和化妆品的成分。这项工作讨论了樟脑的结构和理化性质，它的发生，以及从天然来源以及通过化学合成获得它的方法。还介绍了樟脑在工业制剂中的用途。此外,在详细查阅文献后，樟脑的新陈代谢，它与其他药用物质的相互作用，讨论了其对皮肤病中涉及的细菌和真菌的抗微生物特性。
