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Abstract：
The circulatory system is a closed conduit system throughout the body and consists of two parts as follows: the cardiovascular system and the lymphatic system. Hematological malignancies usually grow and multiply in the circulatory system, directly or indirectly affecting its function. These malignancies include multiple myeloma, leukemia, and lymphoma. O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) regulates the function and stability of substrate proteins through O-GlcNAc modification. Abnormally expressed OGT is strongly associated with tumorigenesis, including hematological malignancies, colorectal cancer, liver cancer, breast cancer, and prostate cancer. In cells, OGT can assemble with a variety of proteins to form complexes to exercise related biological functions, such as OGT/HCF-1, OGT/TET, NSL, and then regulate glucose metabolism, gene transcription, cell proliferation, and other biological processes, thus affecting the development of hematological malignancies. This review summarizes the complexes involved in the assembly of OGT in cells and the role of related OGT complexes in hematological malignancies. Unraveling the complex network regulated by the OGT complex will facilitate a better understanding of hematologic malignancy development and progression.
摘要：
循环系统是贯穿全身的封闭管道系统，由以下两部分组成：心血管系统和淋巴系统。血液恶性肿瘤通常在循环系统中生长和繁殖，直接或间接影响其功能。这些恶性肿瘤包括多发性骨髓瘤,白血病,和淋巴瘤。O-连接的β-N-乙酰葡糖胺(O-GlcNAc)转移酶(OGT)通过O-GlcNAc修饰调节底物蛋白的功能和稳定性。OGT异常表达与肿瘤发生密切相关，包括血液恶性肿瘤,结直肠癌,肝癌,乳腺癌,和前列腺癌。在细胞中，OGT可以与多种蛋白质组装形成复合物，以行使相关的生物学功能，如OGT/HCF-1，OGT/TET，NSL,然后调节葡萄糖代谢，基因转录，细胞增殖，和其他生物过程，从而影响血液系统恶性肿瘤的发展。本文综述了参与OGT在细胞中组装的复合物以及相关OGT复合物在血液系统恶性肿瘤中的作用。解开由OGT复合物调节的复杂网络将有助于更好地理解血液系统恶性肿瘤的发展和进展。
