PDF(Pubmed)
Abstract：
The immune system is affected by the dietary products humans intake. Immune system regulation by nutrition has uses in the clinical context, but it can also benefit healthy populations by delaying or preventing the emergence of immune-mediated chronic illnesses. In this study, the purpose was to describe and compare the modulator effects on the immune system of the routine ingestion of fresh vs. pasteurized yogurt. A unicentral, prospective, randomized, double-blind, parallel group 8-week nutritional study was carried out comparing the ingestion of 125 g of the products in healthy adults three times a day. A complete battery of in vitro tests on the activity of the immune system, processes and phenomena was performed. Exclusive immune-modulatory effects of fresh yogurt with respect to base line were found in terms of increased systemic IgM (primary immune responses), increased synthesis of IFN-gamma upon stimulation (Th1) and increased peripheral T cells (mainly \"naive\" CD4s). In the three interventions, we observed an increased phagocytic activity and burst test in granulocytes, together with increased secretion of IL-6, IL-1 β and IL-8 (pro-inflammatory) and increased CD16 expression (FcR favoring phagocytosis) in granulocytes. Overall, it is concluded that regardless of bacteria being alive or thermally inactivated, yogurt has common effects on the innate system, but the presence of live bacteria is necessary to achieve a potentiating effect on the specific immune response.
摘要：
免疫系统受到人类摄入的膳食产品的影响。通过营养调节免疫系统在临床上有用途，但它也可以通过延缓或预防免疫介导的慢性疾病的出现而使健康人群受益。在这项研究中,目的是描述和比较常规摄入新鲜和新鲜的调节剂对免疫系统的影响。巴氏杀菌酸奶.一个独行者，prospective,随机化，双盲,平行组进行了为期8周的营养研究，比较了每天三次健康成年人摄入125g产品的情况。一组完整的体外测试免疫系统的活性，进行了过程和现象。就增加的全身性IgM（原发性免疫反应）而言，发现新鲜酸奶相对于基线的独家免疫调节作用。刺激后IFN-γ的合成增加（Th1）和外周T细胞增加（主要是“幼稚”CD4s）。在三项干预措施中，我们观察到粒细胞的吞噬活性和爆发试验增加，以及粒细胞中IL-6，IL-1β和IL-8的分泌增加（促炎）和CD16表达增加（FcR有利于吞噬作用）。总的来说,结论是，无论细菌是活的还是热灭活的，酸奶对先天系统有共同的影响，但是活细菌的存在对于实现对特异性免疫反应的增强作用是必要的。
