PDF(Pubmed)
Abstract：
Branched-chain amino acids (BCAAs), as essential amino acids, engage in various physiological processes, such as protein synthesis, energy supply, and cellular signaling. The liver is a crucial site for BCAA metabolism, linking the changes in BCAA homeostasis with the pathogenesis of a variety of liver diseases and their complications. Peripheral circulating BCAA levels show complex trends in different liver diseases. This review delineates the alterations of BCAAs in conditions including non-alcoholic fatty liver disease, hepatocellular carcinoma, cirrhosis, hepatic encephalopathy, hepatitis C virus infection, and acute liver failure, as well as the potential mechanisms underlying these changes. A significant amount of clinical research has utilized BCAA supplements in the treatment of patients with cirrhosis and liver cancer. However, the efficacy of BCAA supplementation in clinical practice remains uncertain and controversial due to the heterogeneity of studies. This review delves into the complicated relationship between BCAAs and liver diseases and tries to untangle what role BCAAs play in the occurrence, development, and outcomes of liver diseases.
摘要：
支链氨基酸(BCAAs),作为必需氨基酸，参与各种生理过程，如蛋白质合成，能源供应,和细胞信号。肝脏是BCAA代谢的重要部位,将BCAA稳态的变化与多种肝病及其并发症的发病机制联系起来。外周循环BCAA水平在不同肝脏疾病中显示出复杂的趋势。这篇综述描述了BCAAs在包括非酒精性脂肪性肝病在内的疾病中的变化。肝细胞癌，肝硬化,肝性脑病,丙型肝炎病毒感染，急性肝功能衰竭,以及这些变化背后的潜在机制。大量的临床研究已经利用BCAA补充剂治疗肝硬化和肝癌患者。然而,由于研究的异质性,BCAA补充剂在临床实践中的疗效仍不确定且存在争议.这篇综述探讨了BCAAs与肝脏疾病之间的复杂关系，并试图阐明BCAAs在其发生中起什么作用。发展,和肝脏疾病的结果。
