PDF(Pubmed)
Abstract：
Low levels of vitamin D in maternal and cord blood have been associated with neonatal sepsis. This study assessed the association of vitamin D metabolites (25(OH)D, 3-epi-25(OH)D3, and 24,25(OH)2D3) levels in maternal and cord blood with newborn sepsis evaluation in Nigerian mother-infant dyads. Maternal and cord blood from 534 mothers and 536 newborns were processed using liquid chromatography-tandem mass spectrometry. Spearman correlation was used to compare continuous variables, Mann-Whitney for dichotomous variables, and Kruskal-Wallis for two or more groups. High cord percent 3-epi-25(OH)D3 levels were positively associated with newborn evaluation for sepsis (p = 0.036), while maternal and cord 25(OH)D and 24,25(OH)2D3 levels were not. Being employed was positively associated with maternal and newborn 3-epi-25(OH)D3 concentrations (p = 0.007 and p = 0.005, respectively). The maternal 3-epi-25(OH)D3 and percent 3-epi-25(OH)D3 were positively associated with vaginal delivery (p = 0.013 and p = 0.012, respectively). Having a weight-for-age Z-score ≤ -2 was positively associated with newborn percent 3-epi-25(OH)D3 levels (p = 0.004), while a weight-for-length Z-score ≤ -3 was positively associated with maternal and newborn percent 3-epi-25(OH)D3 levels (p = 0.044 and p = 0.022, respectively). Our study highlights the need to further investigate the biological role of 3-epi-25(OH)D3 and its clinical significance in fetal growth and newborn outcome.
摘要：
母体和脐带血中低水平的维生素D与新生儿败血症有关。这项研究评估了维生素D代谢物(25(OH)D，3-epi-25（OH）D3和24,25（OH）2D3）在母亲和脐带血中的水平，并评估了尼日利亚母婴二叉中的新生儿败血症。使用液相色谱-串联质谱法处理来自534名母亲和536名新生儿的母亲和脐带血。斯皮尔曼相关性用于比较连续变量，Mann-Whitney对于二分变量，和Kruskal-Wallis为两个或多个组。高脐带百分比3-epi-25（OH）D3水平与新生儿败血症评估呈正相关（p=0.036），而母体和脐带25(OH)D和24,25(OH)2D3水平则没有。被雇用与母体和新生儿3-epi-25（OH）D3浓度呈正相关（分别为p=0.007和p=0.005）。母体3-epi-25（OH）D3和3-epi-25（OH）D3百分比与阴道分娩呈正相关（分别为p=0.013和p=0.012）。年龄体重Z评分≤-2与新生儿百分比3-epi-25（OH）D3水平呈正相关（p=0.004），而身长体重Z评分≤-3与母体和新生儿3-epi-25(OH)D3水平呈正相关(分别为p=0.044和p=0.022).我们的研究强调需要进一步研究3-epi-25（OH）D3的生物学作用及其在胎儿生长和新生儿结局中的临床意义。
