PDF(Pubmed)
Abstract：
BACKGROUND: Spontaneous intracerebral hemorrhage (ICH) is associated with high case fatality and significant healthcare costs. Recent studies emphasize the critical role of nutritional status in affecting outcomes in neurological disorders. This study investigates the relationship between the Prognostic Nutrition Index (PNI) and in-hospital complications and case fatality among patients with ICH.
METHODS: A retrospective analysis was performed using data from the Changhua Christian Hospital Clinical Research Database between January 2015 and December 2022. Patients under 20 or over 100 years of age or with incomplete medical data were excluded. We utilized restricted cubic spline models, Kaplan-Meier survival analysis, and ROC analysis to assess the association between PNI and clinical outcomes. Propensity score matching analysis was performed to balance these clinical variables between groups.
RESULTS: In this study, 2402 patients with spontaneous ICH were assessed using the median PNI value of 42.77. The cohort was evenly divided between low and high PNI groups, predominantly male (59.1%), with an average age of 64 years. Patients with lower PNI scores at admission had higher in-hospital complications and increased 28- and 90-day case fatality rates.
CONCLUSIONS: Our study suggests that PNI could serve as a valuable marker for predicting medical complications and case fatality in patients with spontaneous ICH.
METHODS: A retrospective analysis was performed using data from the Changhua Christian Hospital Clinical Research Database between January 2015 and December 2022. Patients under 20 or over 100 years of age or with incomplete medical data were excluded. We utilized restricted cubic spline models, Kaplan-Meier survival analysis, and ROC analysis to assess the association between PNI and clinical outcomes. Propensity score matching analysis was performed to balance these clinical variables between groups.
RESULTS: In this study, 2402 patients with spontaneous ICH were assessed using the median PNI value of 42.77. The cohort was evenly divided between low and high PNI groups, predominantly male (59.1%), with an average age of 64 years. Patients with lower PNI scores at admission had higher in-hospital complications and increased 28- and 90-day case fatality rates.
CONCLUSIONS: Our study suggests that PNI could serve as a valuable marker for predicting medical complications and case fatality in patients with spontaneous ICH.
摘要：
背景：自发性脑出血（ICH）与高病死率和高医疗费用相关。最近的研究强调了营养状况在影响神经系统疾病结局中的关键作用。这项研究调查了预后营养指数（PNI）与ICH患者院内并发症和病死率之间的关系。
方法：使用2015年1月至2022年12月昌化基督教医院临床研究数据库的数据进行回顾性分析。20岁以下或100岁以上或医疗数据不完整的患者被排除在外。我们利用了有限的三次样条模型，Kaplan-Meier生存分析，和ROC分析评估PNI与临床结局之间的关联。进行倾向评分匹配分析以平衡组间的这些临床变量。
结果：在这项研究中，使用PNI中值42.77评估2402例自发性ICH患者。该队列在低PNI组和高PNI组之间平均分配，以男性为主（59.1%），平均年龄64岁。入院时PNI评分较低的患者住院并发症较高，28天和90天病死率增加。
结论：我们的研究表明，PNI可以作为预测自发性ICH患者医疗并发症和病死率的一个有价值的指标。
方法：使用2015年1月至2022年12月昌化基督教医院临床研究数据库的数据进行回顾性分析。20岁以下或100岁以上或医疗数据不完整的患者被排除在外。我们利用了有限的三次样条模型，Kaplan-Meier生存分析，和ROC分析评估PNI与临床结局之间的关联。进行倾向评分匹配分析以平衡组间的这些临床变量。
结果：在这项研究中，使用PNI中值42.77评估2402例自发性ICH患者。该队列在低PNI组和高PNI组之间平均分配，以男性为主（59.1%），平均年龄64岁。入院时PNI评分较低的患者住院并发症较高，28天和90天病死率增加。
结论：我们的研究表明，PNI可以作为预测自发性ICH患者医疗并发症和病死率的一个有价值的指标。
