PDF(Pubmed)
Abstract：
Upper urinary tract urolithiasis is an emerging disease in cats, with 98% of kidney stones composed of calcium oxalate. In humans, disturbances in the intestinal and urinary microbiota are suspected to contribute to the formation of calcium oxalate stones. We hypothesized that similar mechanisms may be at play in cats. This study examines the intestinal and urinary microbiota of nine cats with kidney stones compared to nine healthy cats before, during, and after treatment with the antibiotic cefovecin, a cephalosporin. Initially, cats with kidney stones displayed a less diverse intestinal microbiota. Antibiotic treatment reduced microbiota diversity in both groups. The absence of specific intestinal bacteria could lead to a loss of the functions these bacteria perform, such as oxalate degradation, which may contribute to the formation of calcium oxalate stones. This study confirms the presence of a distinct urobiome in cats with kidney stones, characterized by greater richness and diversity compared to healthy cats. These findings highlight the potential of microbiota modulation as a strategy to prevent renal lithiasis in cats.
摘要：
上尿路尿路结石是猫的一种新兴疾病，98%的肾结石由草酸钙组成。在人类中,怀疑肠道和尿液微生物群的紊乱有助于草酸钙结石的形成。我们假设类似的机制可能在猫中发挥作用。这项研究检查了9只患有肾结石的猫的肠道和尿液微生物群，与之前的9只健康猫相比，during,用抗生素头孢菌素治疗后，头孢菌素.最初，患有肾结石的猫显示出不那么多样化的肠道微生物群。抗生素治疗降低了两组的微生物群多样性。缺乏特定的肠道细菌可能导致这些细菌的功能丧失，如草酸盐降解，这可能有助于草酸钙结石的形成。这项研究证实了在患有肾结石的猫中存在独特的泌尿生物群落，与健康的猫相比，其特征是更丰富和多样性。这些发现强调了微生物群调节作为预防猫肾结石的策略的潜力。
