PDF(Pubmed)
Abstract：
Transition metal oxide (TMO)-based nanozymes have appeared as hopeful tools for antitumor applications due to their unique catalytic properties and ability to modulate the tumor microenvironment (TME). The purpose of this review is to provide an overview of the latest progress made in the field of TMO-based nanozymes, focusing on their enzymatic activities and participating metal ions. These nanozymes exhibit catalase (CAT)-, peroxidase (POD)-, superoxide dismutase (SOD)-, oxidase (OXD)-, and glutathione oxidase (GSH-OXD)-like activities, enabling them to regulate reactive oxygen species (ROS) levels and glutathione (GSH) concentrations within the TME. Widely studied transition metals in TMO-based nanozymes include Fe, Mn, Cu, Ce, and the hybrid multimetallic oxides, which are also summarized. The review highlights several innovative nanozyme designs and their multifunctional capabilities. Despite the significant progress in TMO-based nanozymes, challenges such as long-term biosafety, targeting precision, catalytic mechanisms, and theoretical supports remain to be addressed, and these are also discussed. This review contributes to the summary and understanding of the rapid development of TMO-based nanozymes, which holds great promise for advancing nanomedicine and improving cancer treatment.
摘要：
基于过渡金属氧化物（TMO）的纳米酶由于其独特的催化特性和调节肿瘤微环境（TME）的能力，已成为抗肿瘤应用的有希望的工具。这篇综述的目的是概述基于TMO的纳米酶领域的最新进展，专注于它们的酶活性和参与的金属离子。这些纳米酶表现出过氧化氢酶（CAT）-，过氧化物酶（POD）-，超氧化物歧化酶（SOD）-，氧化酶（OXD）-，和谷胱甘肽氧化酶（GSH-OXD）样活性，使它们能够调节TME内的活性氧（ROS）水平和谷胱甘肽（GSH）浓度。基于TMO的纳米酶中广泛研究的过渡金属包括Fe，Mn,Cu,Ce,和混合的多金属氧化物，这也是总结。该评论重点介绍了几种创新的纳米酶设计及其多功能功能。尽管基于TMO的纳米酶取得了重大进展，长期生物安全等挑战，瞄准精度，催化机理，理论支持还有待解决，这些也进行了讨论。这篇综述有助于总结和理解基于TMO的纳米酶的快速发展，这对推进纳米医学和改善癌症治疗有着巨大的希望。
