PDF(Pubmed)
Abstract：
Background/Objectives: Gestational diabetes (GDM) is a metabolic disorder with altered glucose levels diagnosed in pregnant women. The pathogenesis of GDM is not fully known, but it is thought to be caused by impaired insulin production and insulin resistance induced by diabetogenic factors. The placenta may play an important role in the development of GDM. Glucose transporters (GLUTs) are responsible for the delivery of glucose into the foetal circulation. Placental zinc transporters regulate insulin and glucagon secretion, as well as gluconeogenesis and glycolysis. The aim of this study was to investigate the placental expression of GLUT3, GLUT4, GLUT7 and SLC30A8 in women with GDM. Furthermore, we evaluated whether the expression profiles of these transporters were correlated with clinical parameters. Methods: This study included 26 patients with GDM and 28 patients with normal glucose tolerance (NGT). Results: The placental expression of GLUT3 was significantly reduced in the GDM group, while the placental expression of GLUT4, GLUT7 and SLC30A8 was significantly upregulated in the GDM group. GLUT3 expression correlated significantly with body mass index (BMI) increase during pregnancy and body mass increase during pregnancy, while GLUT4 expression correlated negatively with BMI at birth. Conclusions: These results suggest the involvement of GLUT3 and GLUT4, GLUT7 and SLC30A8 in the pathogenesis of GDM.
摘要：
背景/目的：妊娠期糖尿病（GDM）是一种代谢紊乱，在孕妇中诊断为葡萄糖水平改变。GDM的发病机制尚不完全清楚，但它被认为是由糖尿病因素引起的胰岛素产生受损和胰岛素抵抗引起的。胎盘可能在GDM的发生发展中起重要作用。葡萄糖转运蛋白(GLUT)负责将葡萄糖递送到胎儿循环中。胎盘锌转运蛋白调节胰岛素和胰高血糖素分泌，以及糖异生和糖酵解。本研究的目的是研究GDM女性胎盘中GLUT3，GLUT4，GLUT7和SLC30A8的表达。此外，我们评估了这些转运体的表达谱是否与临床参数相关.方法：本研究包括26例GDM患者和28例正常糖耐量（NGT）患者。结果:GDM组胎盘组织GLUT3表达明显减少,而GDM组胎盘组织中GLUT4、GLUT7和SLC30A8的表达显著上调。GLUT3表达与孕期体重指数(BMI)增加和孕期体重增加显著相关,而GLUT4的表达与出生时的BMI呈负相关。结论：这些结果表明GLUT3和GLUT4，GLUT7和SLC30A8参与了GDM的发病机理。
