PDF(Pubmed)
Abstract：
Background/Objectives: Recent studies provide the first indications of the impact of climate factors on human health, especially with individuals already grappling with internal and neurological conditions being particularly vulnerable. In the face of escalating climate change, our research delves into the specific influence of a spectrum of climatic factors and seasonal variations on the hospital admissions of patients receiving treatment for epileptic seizures at our clinic in Kaiserslautern. Methods: Our study encompassed data from 9366 epilepsy patients who were admitted to hospital due to epileptic seizures. We considered seven climate parameters that Germany\'s National Meteorological Service made available. We employed the Kruskal-Wallis test to examine the correlation between the frequency of admittance to our hospital in the mentioned patient group and seasons. Furthermore, we used conditional Poisson regression and distributed lag linear models (DLMs) to scrutinize the coherence of the frequency of patient admittance and the investigated climate parameters. The mentioned parameters were also analyzed in a subgroup analysis regarding the gender and age of patients and the classification of seizures according to ILAE 2017. Results: Our results demonstrate that climatic factors, such as precipitation and air pressure, can increase the frequency of hospital admissions for seizures in patients with general-onset epilepsy. In contrast, patients with focal seizures are less prone to climatic changes. Consequently, admittance to the hospital for seizures is less affected by climatic factors in the latter patient group. Conclusions: The present study demonstrated that climatic factors are possible trigger factors for the provocation of seizures, particularly in patients with generalized seizures. This was determined indirectly by analyzing the frequency of seizure-related emergency admissions and their relation to prevailing climate factors. Our study is consistent with other studies showing that climate factors, such as cerebral infarcts or cerebral hemorrhages, influence patients\' health.
摘要：
背景/目标：最近的研究提供了气候因素对人类健康影响的第一个迹象，特别是那些已经在努力应对内部和神经系统疾病的人特别脆弱。面对不断升级的气候变化，我们的研究探讨了一系列气候因素和季节变化对在Kaiserslautern的诊所接受癫痫发作治疗的患者入院的具体影响.方法：我们的研究包括9366例癫痫患者的数据，这些患者因癫痫发作而入院。我们考虑了德国国家气象局提供的七个气候参数。我们使用Kruskal-Wallis检验来检查上述患者组中入院频率与季节之间的相关性。此外，我们使用条件泊松回归和分布滞后线性模型(DLMs)来仔细检查患者入院频率和所研究的气候参数之间的相关性.还在亚组分析中分析了上述参数，涉及患者的性别和年龄以及根据ILAE2017的癫痫发作分类。结果：我们的结果表明，气候因素，如降水和气压，可以增加一般发作性癫痫患者因癫痫发作入院的频率。相比之下,局灶性癫痫患者不易发生气候变化.因此,在后者患者组中，癫痫发作的入院受气候因素的影响较小。结论：本研究表明，气候因素可能是诱发癫痫发作的触发因素，特别是全身性癫痫患者。这是通过分析与癫痫相关的紧急入院的频率及其与主要气候因素的关系间接确定的。我们的研究与其他研究一致，表明气候因素，如脑梗塞或脑出血，影响患者的健康。
