PDF(Pubmed)
Abstract：
Infertility is a prevalent global issue affecting approximately 17.5% of adults, with sole male factor contributing to 20-30% of cases. Oxidative stress (OS) is a critical factor in male infertility, disrupting the balance between reactive oxygen species (ROS) and antioxidants. This imbalance detrimentally affects sperm function and viability, ultimately impairing fertility. OS also triggers molecular changes in sperm, including DNA damage, lipid peroxidation, and alterations in protein expression, further compromising sperm functionality and potential fertilization. Diagnostic tools discussed in this review offer insights into OS markers, antioxidant levels, and intracellular ROS concentrations. By accurately assessing these parameters, clinicians can diagnose male infertility more effectively and thus tailor treatment plans to individual patients. Additionally, this review explores various treatment options for males with OS-associated infertility, such as empirical drugs, antioxidants, nanoantioxidants, and lifestyle modifications. By addressing the root causes of male infertility and implementing targeted interventions, clinicians can optimize treatment outcomes and enhance the chances of conception for couples struggling with infertility.
摘要：
不孕症是一个普遍的全球性问题，影响着大约17.5％的成年人。唯一的男性因素占20-30%的病例。氧化应激（OS）是男性不育的关键因素，破坏活性氧（ROS）和抗氧化剂之间的平衡。这种不平衡会对精子功能和生存能力产生不利影响，最终损害生育能力。OS还会引发精子的分子变化，包括DNA损伤,脂质过氧化，以及蛋白质表达的改变，进一步损害精子功能和潜在的受精。这篇综述中讨论的诊断工具提供了对操作系统标记的见解，抗氧化剂水平，和细胞内ROS浓度。通过准确评估这些参数，临床医生可以更有效地诊断男性不育症，从而为个体患者制定治疗计划。此外,这篇综述探讨了男性OS相关不孕症的各种治疗选择，比如经验性药物，抗氧化剂,纳米抗氧化剂，和生活方式的改变。通过解决男性不育症的根源,实施有针对性的干预措施,临床医生可以优化治疗结果，并增加与不孕症作斗争的夫妇受孕的机会。
