PDF(Pubmed)
Abstract：
This study assessed the impact of Magni-Phi Ultra (MPU) inclusion on intestinal integrity and immunity in broiler chickens challenged with coccidia during peak and recovery phases. A total of 128 male Ross 708 broiler chicks were randomly allotted to one of four treatment groups (four chicks/cage). Treatments included an uninfected control (UUC); a coccidial challenge (CC) infected control (IUC); a CC fed salinomycin at 66 ppm (SAL); and a CC fed Magni-Phi Ultra at 0.11 g/kg of diet (MPU). At 16 days post-hatch, all birds in the CC groups were orally gavaged with a 3× dose of a live coccidia vaccine. At 5 dpi, the birds fed MPU and SAL showed decreased plasma FITC-d, oocyte shedding, and lesion scores and higher BWG compared to the IUC birds (p < 0.05). Jejunum IL-17, IL-10, and IFN-ϒ mRNA expression was higher in the IUC compared to the UUC (p < 0.05) group at 5 dpi. At 12 dpi, the birds fed MPU or SAL had lower plasma FITC-d and jejunum IFN-ϒ and IL-10 mRNA expression compared to the IUC birds (p < 0.05). This study indicates that MPU supports intestinal integrity and mucosal immune responses during the peak and recovery phases of infection, which may lead to improved health and performance.
摘要：
这项研究评估了Magni-PhiUltra（MPU）内含物对高峰和恢复期球虫攻击的肉鸡肠道完整性和免疫力的影响。将总共128只雄性Ross708肉鸡随机分配到四个处理组(四个小鸡/笼)中的一个。治疗包括未感染的对照（UUC）；球虫攻击（CC）感染的对照（IUC）；CC饲喂66ppm的盐霉素（SAL）；和CC饲喂0.11g/kg饮食（MPU）的Magni-PhiUltra。孵化后16天，CC组的所有鸟类均口服3倍剂量的活球虫疫苗。在5dpi，饲喂MPU和SAL的鸟类显示血浆FITC-d降低，卵母细胞脱落，与IUC鸟类相比，病变评分和BWG较高（p<0.05）。在5dpi时，与UUC组相比，IUC中的空肠IL-17，IL-10和IFN-γmRNA表达更高（p<0.05）。在12dpi，与IUC鸟类相比，饲喂MPU或SAL的鸟类血浆FITC-d和空肠IFN-γ和IL-10mRNA表达较低（p<0.05）。这项研究表明，MPU在感染的高峰期和恢复期支持肠道完整性和粘膜免疫反应，这可能会改善健康和表现。
