PDF(Pubmed)
Abstract：
Ideational slippage-characterized by incorrect word usage and strained logic during dialogue-is common in aging and, at greater frequency, is an indicator of pre-clinical cognitive decline. Performance-based assessment of ideational slippage may be useful in the study of cognitive aging and Alzheimer\'s-disease-related pathology. In this preliminary study, we examine the association between corpus callosum volume and a performance-based assessment of ideational slippage in middle-aged and older adults (age 61-79 years). Ideational slippage was indexed from cognitive special scores using the Rorschach Inkblot Method (RIM), which are validated indices of deviant verbalization and logical inaccuracy (Sum6, WSum6). Among middle-aged and older adults, smaller splenium volume was associated with greater ideational slippage (ηp2 = 0.48), independent of processing speed and fluid intelligence. The observed negative associations are consistent with visuospatial perception and cognitive functions of the splenium. The effect was strongest with the splenium, and volumes of the genu and total white matter had small effects that were not statistically significant. Conclusions: Results are discussed with future application of RIM special scores for the assessment of pre-clinical cognitive decline and, based on observed effect sizes, power analyses are reported to inform future study planning.
摘要：
概念滑脱-以对话过程中不正确的单词用法和紧张的逻辑为特征-在衰老中很常见，在更高的频率下，是临床前认知能力下降的指标。基于性能的观念滑脱评估可能有助于认知老化和阿尔茨海默病相关病理的研究。在这项初步研究中，我们研究了中老年人(年龄61~79岁)的call体体积与基于表现的观念滑移评估之间的关联.使用罗夏墨迹法(RIM)从认知特殊分数中索引出想法滑点，这是经过验证的异常言语化和逻辑不准确性指标(Sum6，WSum6)。在中老年人中，较小的Spenium体积与较大的概念性滑移相关(ηp2=0.48)，独立的处理速度和流体智能。观察到的负关联与splenium的视觉空间感知和认知功能一致。Splenium的效果最强，和体积的genu和总白质有小的影响，没有统计学意义。结论：RIM特殊评分在评估临床前认知功能下降方面的未来应用将讨论结果，根据观察到的效应大小，报告功率分析以告知未来的研究计划。
