PDF(Pubmed)
Abstract：
Accelerated brain aging is a possible mechanism of pathology in schizophrenia. Advances in MRI-based brain development algorithms allow for the calculation of predicted brain age (PBA) for individuals. Here, we assessed PBA in 70 first-episode schizophrenia-spectrum individuals (FESz) and 76 matched healthy neurotypical comparison individuals (HC) to determine if FESz showed advanced aging proximal to psychosis onset and whether PBA was associated with neurocognitive, social functioning, or symptom severity measures. PBA was calculated with BrainAgeR (v2.1) from T1-weighted MR scans. There were no differences in the PBAs between groups. After controlling for actual age, a \"younger\" PBA was associated with higher vocabulary scores among all individuals, while an \"older\" PBA was associated with more severe negative symptom \"Inexpressivity\" component scores among FESz. Female participants in both groups had an elevated PBA relative to male participants. These results suggest that a relatively younger brain age is associated with a better semantic memory performance. There is no evidence for accelerated aging in FESz with a late adolescent/early adult onset. Despite a normative PBA, FESz with a greater residual PBA showed impairments in a cluster of negative symptoms, which may indicate some underlying age-related pathology proximal to psychosis onset. Although a period of accelerated aging cannot be ruled out with disease course, it does not occur at the time of the first episode.
摘要：
脑老化加速是精神分裂症的一种可能病理机制。基于MRI的大脑发育算法的进展允许计算个体的预测大脑年龄(PBA)。这里,我们评估了70名首发精神分裂症患者（FESz）和76名匹配的健康神经典型对照个体（HC）的PBA，以确定FESz是否显示出接近精神病发作的晚期衰老以及PBA是否与神经认知相关，社会功能,或症状严重程度的措施。用BrainAgeR(v2.1)从T1加权MR扫描计算PBA。两组之间的PBA没有差异。在控制实际年龄后，“年轻”的PBA与所有个体中更高的词汇分数相关，而“年龄较大”的PBA与FESz中更严重的阴性症状“表现力”成分得分相关。相对于男性参与者，两组女性参与者的PBA升高。这些结果表明，相对年轻的大脑年龄与更好的语义记忆表现有关。没有证据表明FESz在青春期晚期/成年早期发作时会加速衰老。尽管有规范的PBA，残留PBA较高的FESz显示出一系列阴性症状的损害，这可能表明一些潜在的年龄相关的病理接近精神病发作。尽管不能排除疾病过程中的加速衰老时期，它不会发生在第一集的时候。
